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| | (S)-1-N-Boc-2-methylpiperazine Basic information |
| | (S)-1-N-Boc-2-methylpiperazine Chemical Properties |
| Melting point | 43.0 to 47.0 °C | | Boiling point | 268.7±15.0 °C(Predicted) | | density | 0.997±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | solubility | soluble in Methanol | | form | powder to crystal | | pka | 8.49±0.40(Predicted) | | color | White to Almost white | | Optical Rotation | Consistent with structure | | InChI | InChI=1S/C10H20N2O2/c1-8-7-11-5-6-12(8)9(13)14-10(2,3)4/h8,11H,5-7H2,1-4H3/t8-/m0/s1 | | InChIKey | DATRVIMZZZVHMP-QMMMGPOBSA-N | | SMILES | N1(C(OC(C)(C)C)=O)CCNC[C@@H]1C | | CAS DataBase Reference | 169447-70-5(CAS DataBase Reference) |
| RIDADR | UN3077 | | HS Code | 2933599590 |
| | (S)-1-N-Boc-2-methylpiperazine Usage And Synthesis |
| Uses | (S)-1-N-Boc-2-methylpiperazine is used in the preparation of pyrazolo[3,4-b]pyridine dual pharmacophores as PDE4-muscarinic antagonists. | | Synthesis | A solution of (S)-2-methyl piperazine (2 g, 20 mmol) in THF (200 ml_) was mixed with nBuLi (25 ml, 1.6 M in hexanes, 40 mmol) at rt. The solution was stirred for 30 minutes before TBDMSCI (3.04 g, 20 mmol) was added. The mixture was stirred for 1 hour and then (Boc)2O (5.2 g, 24 mmol) was added to the solution. After 1 hour, the solution was diluted with H2O (50 ml). The organic layer was separated, washed with brine (50 mL), dried over Na2SO4, and concentrated EPO under vacuum. Finally, (S)-1-N-Boc-2-methylpiperazine was obtained after purification. | | References | [1] Patent: WO2006/55553, 2006, A2. Location in patent: Page/Page column 36; 37
[2] Journal of Organic Chemistry, 1995, vol. 60, # 13, p. 4177 - 4183 |
| | (S)-1-N-Boc-2-methylpiperazine Preparation Products And Raw materials |
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