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| | 4-NITROPHENYLGLYOXAL HYDRATE Basic information |
| Product Name: | 4-NITROPHENYLGLYOXAL HYDRATE | | Synonyms: | 2,2-dihydroxy-1-(4-nitrophenyl)ethanone;(4-Nitrophenyl)(oxo)acetaldehyde hydrate, 4-(Oxoacetyl)nitrobenzene hydrate;Ethanone, 2,2-dihydroxy-1-(4-nitrophenyl)-;2-(4-Nitrophenyl)-2-oxoacetaldehydehydrate;4-NITROPHENYLGLYOXAL H2O;4-NITROPHENYLGLYOXAL HYDRATE;4-Nitrophenylglyoxal hydrate 95%;4-NITROPHENYLGLYOXAL HYDRATE, 95+% | | CAS: | 4996-22-9 | | MF: | C8H7NO5 | | MW: | 197.14 | | EINECS: | | | Product Categories: | | | Mol File: | 4996-22-9.mol |  |
| | 4-NITROPHENYLGLYOXAL HYDRATE Chemical Properties |
| Melting point | 97-100 °C | | Boiling point | 356.7±27.0 °C(Predicted) | | density | 1.537±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | pka | 10.16±0.41(Predicted) | | Appearance | Off-white to light yellow Solid |
| | 4-NITROPHENYLGLYOXAL HYDRATE Usage And Synthesis |
| Synthesis | GENERAL METHODS: A mixture of 4-nitroacetophenone (0.6 mmol) and ethylene bromide (0.06 mmol) in DMSO (1.1 mL) was placed in an open-top flask and heated in an oil bath (see Table 2 for specific temperatures and reaction times). After completion of the reaction (monitored by TLC), the reaction mixture was diluted with water (11 mL), salted with saturated NaCl solution and extracted with ethyl acetate (5 × 4 mL). Only in case of synthesis of arylglyoxal, the organic layer was additionally washed with aqueous Na2CO3 (0.12 mmol, dissolved in 2 mL of water), followed by saturated aqueous NaCl solution and dried with anhydrous Na2SO4. The extract was purified by column chromatography (eluent: petroleum ether/ethyl acetate gradient) to give pure 2,2-dihydroxy-1-(4-nitrophenyl)ethanone. | | References | [1] Tetrahedron Asymmetry, 2010, vol. 21, # 18, p. 2244 - 2248
[2] Tetrahedron, 2011, vol. 67, # 41, p. 8000 - 8008
[3] Journal of Fluorine Chemistry, 2010, vol. 131, # 12, p. 1289 - 1296
[4] Tetrahedron Letters, 2011, vol. 52, # 31, p. 4036 - 4038
[5] Tetrahedron, 2013, vol. 69, # 1, p. 22 - 28 |
| | 4-NITROPHENYLGLYOXAL HYDRATE Preparation Products And Raw materials |
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