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| | C6-NBD sphingosine, beta-D-glucosyl Basic information |
| Product Name: | C6-NBD sphingosine, beta-D-glucosyl | | Synonyms: | C6?NBD-Sphingosine,?beta-D-lactosyl;C6-NBD Sphingosine, beta-D-glucosyl, N-[6-[(7-Nitro-2-1,3-benzoxadiazol-4-yl)amino]caproyl]-D-glucosyl-β1-1μ-sphingosine;N-(NBD-Aminocaproyl)sphingosine β-D-glucosyl;N-C6-NBD-BETA-D-GLUCOSYL-SPHINGOSINE;N-(NBD-AMINOCAPROYL)SPHINGOSINE BETA-D-GLUCOSYL;N-HEXANOYL-NBD-BETA-D-GLUCOSYL-SPHINGOSINE;N-[6-[(7-NITRO-2-1,3-BENZOXADIAZOL-4-YL)AMINO]CAPROYL]-D-GLUCOSYL-B1-1'-SPHINGOSINE;C6-NBD-GLUCOSYLCERAMIDE, FLUORESCENT | | CAS: | 94885-03-7 | | MF: | C36H59N5O11 | | MW: | 737.88 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File |  |
| | C6-NBD sphingosine, beta-D-glucosyl Chemical Properties |
| density | 1.27±0.1 g/cm3(Predicted) | | storage temp. | −20°C | | solubility | Chloroform:Methanol (5:1): Soluble; Methanol: Soluble | | form | A solid | | pka | 12.92±0.70(Predicted) | | color | Yellow to orange | | Appearance | Solid Powder |
| WGK Germany | 3 | | Storage Class | 11 - Combustible Solids |
| | C6-NBD sphingosine, beta-D-glucosyl Usage And Synthesis |
| Description | C6 NBD glucosylceramide (d18:1/6:0) is a biologically active derivative of glucosylceramide that is tagged with a fluorescent C-6 nitrobenzoxadiazole (C-6 NBD; ) group. C6 NBD glucosylceramide (d18:1/6:0) has been used to study the metabolism and internalization of glucosylceramide. [Matreya, LLC. Catalog No. 1622] | | Uses | C6 NBD Glucosylceramide is a glucosylceramide fluorescent derivative (Ex=466 nm, Em=535 nm). C6 NBD Glucosylceramide can be used to study the metabolism and internalization of glucosylceramide and also for the determination of glucosyl ceramide synthase activity[1][2][3]. | | References | [1] Kok JW, et al. Salvage of glucosylceramide by recycling after internalization along the pathway of receptor-mediated endocytosis. Proc Natl Acad Sci U S A. 1989 Dec;86(24):9896-900. DOI:10.1073/pnas.86.24.9896
[2] Hayashi Y, et al. A sensitive and reproducible assay to measure the activity of glucosylceramide synthase and lactosylceramide synthase using HPLC and fluorescent substrates. Anal Biochem. 2005 Oct 15;345(2):181-6. DOI:10.1016/j.ab.2005.05.029
[3] di Bartolomeo S, et al. Differential chemosensitizing effect of two glucosylceramide synthase inhibitors in hepatoma cells. Biochem Biophys Res Commun. 2001 Oct 19;288(1):269-74. DOI:10.1006/bbrc.2001.5748 |
| | C6-NBD sphingosine, beta-D-glucosyl Preparation Products And Raw materials |
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