| Company Name: |
amyjet |
| Tel: |
4006800868;027-59626688 18771149750 |
| Email: |
sales@amyjet.com |
|
| | 20-Carboxy-leukotriene B4 Basic information |
| Product Name: | 20-Carboxy-leukotriene B4 | | Synonyms: | 20-COOH-LTB4;5S,12R-DIHYDROXY-6Z,8E,10E,14Z-EICOSATETRAENE-1,20-DIOIC ACID;(5S,6Z,8E,10E,12R,14Z)-5,12-dihydroxyicosa-6,8,10,14-tetraenedioic acid;20-hydroxy-20-oxoleukotriene B4;6,8,10,14-Eicosatetraenedioic acid, 5,12-dihydroxy-, (5S,6Z,8E,10E,12R,14Z)-;20-carboxy Leukotriene B4 (20-carboxy LTB4);20-Carboxy-leukotriene B4 | | CAS: | 80434-82-8 | | MF: | C20H30O6 | | MW: | 366.45 | | EINECS: | | | Product Categories: | Fatty Acids;Leukotrienes;Lipids | | Mol File: | 80434-82-8.mol |  |
| | 20-Carboxy-leukotriene B4 Chemical Properties |
| Boiling point | 588.3±50.0 °C(Predicted) | | density | 1.151±0.06 g/cm3(Predicted) | | Fp | 14℃ | | storage temp. | −20°C | | solubility | DMF: 50 mg/ml; DMSO: 50 mg/ml; Ethanol: 50 mg/ml; PBS pH 7.2: 1 mg/ml | | form | Liquid | | pka | 4.66±0.10(Predicted) | | color | Colorless to light yellow |
| | 20-Carboxy-leukotriene B4 Usage And Synthesis |
| Description | 20-carboxy LTB4 is a metabolite of LTB4 in human neutrophils. In human leukocytes, LTB4 is inactivated by the enzyme LTB4 20-hydroxylase. The resulting 20-hydroxy LTB4 is further oxidized to 20-carboxy LTB4. LTB4 metabolism in isolated rat hepatocytes also results in production of 20-carboxy LTB4 along with other ω-oxidation products. The biological activity of 20-carboxy LTB4 is only about 2.6% compared to that of LTB4 in causing PMNL degranulation. | | Uses | 20-COOH-LTB4 is a leukotriene B4 metabolite and substrate for β-oxidation pathways. | | Definition | ChEBI: A member of the class of leukotrienes that is leukotriene B4 in which the terminal methyl group has undergone formal oxidation to the corresponding carboxylic acid. | | IC 50 | Human Endogenous Metabolite; BLT1 | | References | [1] GRAN HANSSON . Identification and biological activity of novel ω-oxidized metabolites of leukotriene B4 from human leukocytes[J]. FEBS Letters, 1981, 130 1: Pages 107-112. DOI: 10.1016/0014-5793(81)80676-x
[2] T. HARPER R M M Garrity. Metabolism of leukotriene B4 in isolated rat hepatocytes. Identification of a novel 18-carboxy-19,20-dinor leukotriene B4 metabolite.[J]. The Journal of Biological Chemistry, 1986, 140 1: 5414-5418. DOI: 10.1016/s0021-9258(19)57231-3
[3] STEVEN J. FEINMARK. Stimulation of human leukocyte degranulation by leukotriene B4 and its ω-oxidized metabolites[J]. FEBS Letters, 1981, 136 1: Pages 141-144. DOI: 10.1016/0014-5793(81)81233-1 |
| | 20-Carboxy-leukotriene B4 Preparation Products And Raw materials |
|