(+/-)-VESAMICOL HYDROCHLORIDE
| 中文名称 | (+/-)-VESAMICOL HYDROCHLORIDE |
|---|---|
| 中文同义词 | 化合物 T22486;盐酸扎氟普汀;REL-(1R,2R)-2-(4-苯基哌啶-1-基)环己-1-醇盐酸盐;(±)-VESAMICOL HYDROCHLORIDE;(+/-)-Vesamicol hydrochloride |
| 英文名称 | (+/-)-Vesamicol hydrochloride |
| 英文同义词 | AH-5183;AH-5183 HYDROCHLORIDE;(+/-)-2-(4-PHENYLPIPERIDINO)CYCLOHEXANOL HYDROCHLORIDE;(+/-)-VESAMICOL HCL;(+/-)-VESAMICOL HYDROCHLORIDE (AH-5183) >98%;(±)-2-(4-Phenylpiperidino)cyclohexanol hydrochloride, AH-5183 hydrochloride;Ah-5183((+/-)-2-(4-phenylpiperidino) cyclohexanol;(±)-VesamicolHCl (AH-5183) |
| CAS号 | 120447-62-3 |
| 分子式 | C17H25NO.ClH |
| 分子量 | 295.85 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 120447-62-3.mol |
| 结构式 |  |
(+/-)-VESAMICOL HYDROCHLORIDE 性质
| 储存条件 | Store at RT |
|---|---|
| 溶解度 | 低于pH8的水性缓冲液：1 mM |
| 形态 | 固体 |
| 颜色 | 白色 |
(±)-Vesamicol hydrochloride ((±)-AH5183 hydrochloride) 是一种有效的囊泡乙酰胆碱转运 (vesicular acetylcholine transport) 抑制剂，Ki 为 2 nM。(±)-Vesamicol hydrochloride 也对 σ1 和 σ2 受体具有高亲和力，Ki 值分别为 26 nM 和 34 nM。
Ki: 2 nM (Vesicular acetylcholine transport), 26 nM (σ1 receptors) and 34 nM (σ2 receptors)
The pharmacological actions of (±)-Vesamicol have been attributed to inhibition of acetylcholine transport into synaptic vesicles and the subsequent quantal release of acetylcholine.
(±)-Vesamicol (3 mg/kg; intraperitoneal injection; once; male Wistar rats) treatment increases the levels of cytosolic acetylcholine (ACh) in all regions of the brain, while those of vesicular ACh decreased in all regions except for the striatum.
| Animal Model: | Male Wistar rats (120-300 g) |
| Dosage: | 3 mg/kg |
| Administration: | Intraperitoneal injection; once |
| Result: | The levels of cytosolic acetylcholine (ACh) increased in all regions of the brain, while those of vesicular ACh decreased in all regions except for the striatum. |
安全信息
| WGK Germany | 3 |
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| 提供商 | 语言 |
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英文
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