BPN-15606 manufacturers
- BPN-15606
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- $4250.00
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2026-07-15
- CAS:1914989-49-3
- Purity:
- Supply Ability: 10g
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| | BPN-15606 Basic information |
| Product Name: | BPN-15606 | | Synonyms: | BPN-15606;BPN15606,BPN 15606;3-Pyridazinamine, N-[(1S)-1-(4-fluorophenyl)ethyl]-6-[6-methoxy-5-(4-methyl-1H-imidazol-1-yl)-2-pyridinyl]-4-methyl- | | CAS: | 1914989-49-3 | | MF: | C23H23FN6O | | MW: | 418.47 | | EINECS: | | | Product Categories: | | | Mol File: | 1914989-49-3.mol |  |
| | BPN-15606 Chemical Properties |
| Boiling point | 620.5±55.0 °C(Predicted) | | density | 1.27±0.1 g/cm3(Predicted) | | pka | 4.19±0.10(Predicted) | | form | Solid | | color | White to yellow |
| | BPN-15606 Usage And Synthesis |
| Description | BPN-15606 is a highly potent, orally active γ-secretase modulator (GSM). GSM attenuates the production of Aβ42 by SHSY5Y neuroblastoma cells. | | Uses | BPN-15606 is a highly potent, orally active γ-secretase modulator (GSM), attenuates the production of Aβ42 and Aβ40 by SHSY5Y neuroblastoma cells with IC50 values of 7 nM and 17nM, respectively. BPN-15606 lowers Aβ42 and Aβ40 levels in the central nervous system of rats and mice. BPN-15606 has acceptable PK/PD properties, including bioavailability, half-life, and clearance[1]. | | in vivo | BPN-15606 (oral administration; 10 mg/kg, 25 mg/kg and 50 mg/kg; 7 days) shows excellent dose-dependent efficacy in both plasma and brain on lowering of Aβ42 and Aβ40 levels in mice[1].
BPN-15606 (oral administration; 5 mg/kg, 25 mg/kg and 50 mg/kg; 9 days) dose-dependently reduces CSF on lowering of Aβ42 and Aβ40 levels in rats[1].
BPN-15606 (oral administration; 25 mg/kg; single dose) shows a robust effect on both brain and plasma Aβ 42 and Aβ40 levels, which begins approximately 30–60 minutes following the single dose administration and lasted for ≥24 hours in C57BL/6 mice[1]. | | References | [1] Wagner SL, et al. Pharmacological and Toxicological Properties of the Potent Oral γ-Secretase Modulator BPN-15606. J Pharmacol Exp Ther. 2017 Jul;362(1):31-44. DOI:10.1124/jpet.117.240861 |
| | BPN-15606 Preparation Products And Raw materials |
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