6,7-Dihydro-4H-pyrano[4,3-d]thiazol-2-ylamine

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6,7-Dihydro-4H-pyrano[4,3-d]thiazol-2-ylamine Basic information
Product Name:6,7-Dihydro-4H-pyrano[4,3-d]thiazol-2-ylamine
Synonyms:6,7-dihydro-4H-pyrano[4,3-d][1,3]thiazol-2-amine;6,7-Dihydro-4H-pyrano[4,3-d]-1,3-thiazol-2-ylamine;6,7-DIHYDRO-4H-PYRANO[4,3-D]THIAZOL-2-AMINE;4H,6H,7H-pyrano[4,3-d][1,3]thiazol-2-aMine;4H-Pyrano[4,3-d]thiazol-2-amine, 6,7-dihydro-;6,7-Dihydro-4H-pyrano[4,3-d]thiazol-2-ylamine
CAS:259810-12-3
MF:C6H8N2OS
MW:156.21
EINECS:
Product Categories:pharmacetical
Mol File:259810-12-3.mol
6,7-Dihydro-4H-pyrano[4,3-d]thiazol-2-ylamine Structure
6,7-Dihydro-4H-pyrano[4,3-d]thiazol-2-ylamine Chemical Properties
Boiling point 353.7±32.0 °C(Predicted)
density 1.391±0.06 g/cm3(Predicted)
storage temp. 2-8°C, protect from light
pka4.73±0.20(Predicted)
AppearanceLight yellow to yellow Solid
Safety Information
HS Code 2934999090
MSDS Information
6,7-Dihydro-4H-pyrano[4,3-d]thiazol-2-ylamine Usage And Synthesis
Synthesis
Tetrahydro-4H-pyran-4-one

29943-42-8

Cyanamide

420-04-2

6,7-DIHYDRO-4H-PYRANO[4,3-D]THIAZOL-2-YLAMINE

259810-12-3

GENERAL STEPS: Tetrahydro-4H-pyran-4-one (500 mg, 4.99 mmol), sulfur powder (160 mg, 4.99 mmol), cyanamide (210 mg, 4.99 mmol), and pyrrolidine (4 μL, 0.05 mmol) were dissolved in isopropanol (3 mL) and the reaction was stirred for 1.5 hours at room temperature. Upon completion of the reaction, the mixture was partitioned between water and ethyl acetate (EtOAc) and the aqueous phase was extracted with additional ethyl acetate. The organic phases were combined, washed sequentially with water and saturated brine and dried over anhydrous magnesium sulfate (MgSO). The crude product was purified by fast column chromatography eluting with a gradient of mixed solvents (0-10% MeOH) of dichloromethane (DCM) and methanol (MeOH) to afford 6,7-dihydro-4H-pyrano[4,3-D]thiazol-2-amine as a yellow oil, which was crystallized after standing (500 mg, 64% yield). Mass spectrum (MS): m/z = 156.9 ([M + H]+).

References[1] Patent: WO2016/1341, 2016, A1. Location in patent: Page/Page column 85
[2] Patent: WO2009/67613, 2009, A1. Location in patent: Page/Page column 129
6,7-Dihydro-4H-pyrano[4,3-d]thiazol-2-ylamine Preparation Products And Raw materials
Raw materialsTetrahydro-4H-pyran-4-one-->Cyanamide-->Pyrrolidine-->Sulfur-->Isopropyl alcohol
Tag:6,7-Dihydro-4H-pyrano[4,3-d]thiazol-2-ylamine(259810-12-3) Related Product Information
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