1H-Benz[de]isoquinoline-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-hydroxy-

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Products Intro: Product Name:WUN29654
CAS:2407829-65-4
Purity:98% Package:10MG;50MG;100MG,1G,5G,10G
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CAS:2407829-65-4
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Products Intro: Product Name:CRBN modulator-1；WUN29654
CAS:2407829-65-4
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Products Intro: Product Name:2-(2,6-Dioxopiperidin-3-yl)-5-hydroxy-1H-benzo[de]isoquinoline-1,3(2H)-dione
CAS:2407829-65-4
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Products Intro: Product Name:2-(2,6-dioxopiperidin-3-yl)-5-hydroxy-1H-benzo[de]isoquinoline-1,3(2H)-dione
CAS:2407829-65-4
Purity:95%+ Package:5g;10g;1kg;10kg
1H-Benz[de]isoquinoline-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-hydroxy- Basic information
Product Name:1H-Benz[de]isoquinoline-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-hydroxy-
Synonyms:1H-Benz[de]isoquinoline-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-hydroxy-;WUN-29654;CRBN modulator-1;2-(2,6-Dioxopiperidin-3-yl)-5-hydroxy-1H-benzo[de]isoquinoline-1,3(2H)-dione;CRBN modulator1,CRBN modulator-1,inhibit,CRBN modulator 1,Ligands for E3 Ligase,E3 ligase-recruiting Moiety,Inhibitor;3-(2,6-dioxopiperidin-3-yl)-7-hydroxy-3-azatricyclo[7.3.1.0?,13]trideca-1(13),5,7,9,11-pentaene-2,4-dione;3-(2,6-dioxopiperidin-3-yl)-11-hydroxy-3-azatricyclo[7.3.1.0^{5,13}]trideca-1(13),5,7,9,11-pentaene-2,4-dione;CRBN modulator-1, 10 mM in DMSO
CAS:2407829-65-4
MF:C17H12N2O5
MW:324.29
EINECS:
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Mol File:2407829-65-4.mol
1H-Benz[de]isoquinoline-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-hydroxy- Structure
1H-Benz[de]isoquinoline-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-hydroxy- Chemical Properties
Boiling point 680.0±50.0 °C(Predicted)
density 1.587±0.06 g/cm3(Predicted)
solubility DMSO : 10 mg/mL (30.84 mM; ultrasonic and adjust pH to 2 with HCl)
form Solid
pka8.27±0.20(Predicted)
color Light green to green
Safety Information
MSDS Information
1H-Benz[de]isoquinoline-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-hydroxy- Usage And Synthesis
UsesCRBN modulator-1, a Thalidomide analog and a CRBN modulator extracted from WO2020006262A1, compound 10, has an IC50 of 3.5 μM and a Ki of 0.98 μM[1].
Biological ActivityCRBN modulator-1, a Thalidomide analog and a CRBN modulator extracted from WO2020006262A1, compound 10, has an IC50 of 3.5 μM and a Ki of 0.98 μM[1].
IC 50Cereblon
References[1]. Nathanael Gray, et al. New crbn modulators. WO2020006262A1.
1H-Benz[de]isoquinoline-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-hydroxy- Preparation Products And Raw materials
Tag:1H-Benz[de]isoquinoline-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-hydroxy-(2407829-65-4) Related Product Information
3-(4-methoxy-1-oxoisoindolin-2-yl)piperidine-2,6-dione 1H-Benz[de]isoquinoline-1,3(2H)-dione, 5-amino-2-(2,6-dioxo-3-piperidinyl)- 2,6-Piperidinedione, 3-(1,3-dihydro-1-oxo-2H-isoindol-2-yl)-1-[(4-methoxyphenyl)methyl]- 2-(2,6-dioxopiperidin-3-yl)-5-hydroxyisoindoline-1,3-dione 3-(6-hydroxy-1-oxoisoindolin-2-yl)piperidine-2,6-dione (R)-2-(2,6-Dioxopiperidin-3-yl)-4-hydroxyisoindoline-1,3-dione