1H-Pyrrolo[2,3-b]pyridine-3-carboxamide, N-[3-(phenylmethyl)-2(3H)-thiazolylidene]- manufacturers
- Lats-IN-1
-
- $48.00
-
2026-07-27
- CAS:1424635-83-5
- Purity: 99.82%
- Supply Ability: 10g
|
| | 1H-Pyrrolo[2,3-b]pyridine-3-carboxamide, N-[3-(phenylmethyl)-2(3H)-thiazolylidene]- Basic information |
| Product Name: | 1H-Pyrrolo[2,3-b]pyridine-3-carboxamide, N-[3-(phenylmethyl)-2(3H)-thiazolylidene]- | | Synonyms: | 1H-Pyrrolo[2,3-b]pyridine-3-carboxamide, N-[3-(phenylmethyl)-2(3H)-thiazolylidene]-;TRULI;Lats-IN-1(TRULI );Lats-IN-1;N-(3-Benzylthiazol-2(3H)-ylidene)-1H-pyrrolo[2,3-b]pyridine-3-carboxamide;(Z)-N-(3-benzylthiazol-2(3H)-ylidene)-1H-pyrrolo[2,3-b]pyridine-3-carboxamide;inhibit,LatsIN1,YAP,Yes-associated protein,Lats IN 1,Inhibitor;Lats-IN-1, 10 mM in DMSO | | CAS: | 1424635-83-5 | | MF: | C18H14N4OS | | MW: | 334.4 | | EINECS: | | | Product Categories: | | | Mol File: | 1424635-83-5.mol | ![1H-Pyrrolo[2,3-b]pyridine-3-carboxamide, N-[3-(phenylmethyl)-2(3H)-thiazolylidene]- Structure](CAS/20210111/GIF/1424635-83-5.gif) |
| | 1H-Pyrrolo[2,3-b]pyridine-3-carboxamide, N-[3-(phenylmethyl)-2(3H)-thiazolylidene]- Chemical Properties |
| density | 1.36±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO: 83.33 mg/mL (249.20 mM) | | form | A solid | | pka | 12.30±0.40(Predicted) | | color | White to light yellow | | InChI | 1S/C18H14N4OS/c23-17(15-11-20-16-14(15)7-4-8-19-16)21-18-22(9-10-24-18)12-13-5-2-1-3-6-13/h1-11H,12H2,(H,19,20) | | InChIKey | VTXBMVZVPUSAJF-UHFFFAOYSA-N | | SMILES | O=C(C1=CNC2=C1C=CC=N2)N=C3SC=CN3CC4=CC=CC=C4 |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | 1H-Pyrrolo[2,3-b]pyridine-3-carboxamide, N-[3-(phenylmethyl)-2(3H)-thiazolylidene]- Usage And Synthesis |
| Uses | TRULI (Lats-IN-1) is a potent and ATP-competitive inhibitor of Lats1 and Lats2 kinases. TRULI promotes Yap-dependent proliferation in postmitotic mammalian tissues[1]. | | Biological Activity | TRULI is a call penetrant, potent and non-toxic activator of Yap signaling. TRULI is an ATP-competitive inhibitor of Lats kinases (the core enzymes in Hippo signaling) th at induces robust Yap nuclear translocation and prevents Yap phosphorylation. TRULI induces proliferation of supporting cells in the murine inner ear, murine cardiomyocytes, and human Müller glia in retinal organoids. | | References | [1] Nathaniel Kastan, et al. Small-molecule inhibition of Lats kinases promotes Yap-dependent proliferation in postmitotic mammalian tissues. bioRxiv 2020.02.11.944157. |
| | 1H-Pyrrolo[2,3-b]pyridine-3-carboxamide, N-[3-(phenylmethyl)-2(3H)-thiazolylidene]- Preparation Products And Raw materials |
|