Acetic acid, 2-[bis(2,2,2-trifluoroethoxy)phosphinyl]-, 1,1-dimethylethyl ester manufacturers
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| | Acetic acid, 2-[bis(2,2,2-trifluoroethoxy)phosphinyl]-, 1,1-dimethylethyl ester Basic information |
| Product Name: | Acetic acid, 2-[bis(2,2,2-trifluoroethoxy)phosphinyl]-, 1,1-dimethylethyl ester | | Synonyms: | Acetic acid, 2-[bis(2,2,2-trifluoroethoxy)phosphinyl]-, 1,1-dimethylethyl ester;1,1-Dimethylethyl 2-[bis(2,2,2-trifluoroethoxy)phosphinyl]acetate;1,1-Dimethylethyl 2-[bis(2,2,2-trifluoroethoxy)phosphinyl]acetate - [D94071];Acetic acid, 2-[bis(2,2,2-trifluoroethoxy)phosphiny | | CAS: | 187107-33-1 | | MF: | C10H15F6O5P | | MW: | 360.19 | | EINECS: | | | Product Categories: | | | Mol File: | 187107-33-1.mol | ![Acetic acid, 2-[bis(2,2,2-trifluoroethoxy)phosphinyl]-, 1,1-dimethylethyl ester Structure](CAS/20200611/GIF/187107-33-1.gif) |
| | Acetic acid, 2-[bis(2,2,2-trifluoroethoxy)phosphinyl]-, 1,1-dimethylethyl ester Chemical Properties |
| Boiling point | 291.1±40.0 °C(Predicted) | | density | 1.350±0.06 g/cm3(Predicted) |
| | Acetic acid, 2-[bis(2,2,2-trifluoroethoxy)phosphinyl]-, 1,1-dimethylethyl ester Usage And Synthesis |
| Synthesis | To a stirred solution of 18-crown-6 (7.18 g, 27.16 mmol), THF (30 mL), bis
(2,2,2-trifluoroethyl) phosphite (1) (0.95 mL, 5.97 mmol), KHMDS (13.0 mL, 6.50
mmol, 0.5 M in toluene) was added by syringe in a dropwise manner at -78 oC. After 15
min, tert-butyl bromoacetate (0.80 mL, 5.41 mmol) was added to the round bottom flask
and the reaction mixture warmed to room temperature over 4 hr. After workup procedure
as outlined in the general method, the crude product was then purified by flash column
chromatography (6:1-3:1 hexanes:EtOAc, Rf
= 0.19 in 3:1 hexanes:EtOAc) yielding
Tert-butyl 2-(bis(2,2,2-trifluoroethyl) phosphoryl) acetate (1.345 g, 3.73 mmol, 69.0%) as a yellow syrup. |
| | Acetic acid, 2-[bis(2,2,2-trifluoroethoxy)phosphinyl]-, 1,1-dimethylethyl ester Preparation Products And Raw materials |
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