PSB CB5 manufacturers
- PSB-CB5
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- $81.00
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2026-05-11
- CAS:1627710-30-8
- Purity: 99.26%
- Supply Ability: 10g
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| | PSB CB5 Basic information |
| Product Name: | PSB CB5 | | Synonyms: | PSB CB5;CID-85469571;GPR18 IN 32;GPR18IN32;GPR18-IN-32;5H-Imidazo[2,1-b][1,3]thiazin-3(2H)-one, 2-[[3-[(4-chlorophenyl)methoxy]phenyl]methylene]-6,7-dihydro-, (2Z)-;CID-85469571|||GPR18-IN-32 | | CAS: | 1627710-30-8 | | MF: | C20H17ClN2O2S | | MW: | 384.88 | | EINECS: | | | Product Categories: | | | Mol File: | 1627710-30-8.mol |  |
| | PSB CB5 Chemical Properties |
| Boiling point | 549.9±60.0 °C(Predicted) | | density | 1.35±0.1 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | Soluble in DMSO (up to 25 mg/ml) | | form | solid | | pka | -1.84±0.20(Predicted) | | color | Pale yellow | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. | | InChIKey | XJBQRMOGMULGPP-PDGQHHTCSA-N | | SMILES | O=C1N2C(SCCC2)=N/C1=C\C3=CC(OCC4=CC=C(C=C4)Cl)=CC=C3 |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | PSB CB5 Usage And Synthesis |
| Description | PSB-CB5 (1627710-30-8) is a potent and selective GPR18 antagonist (IC50= 0.279 μM) exhibiting >36-fold selectivity against GPR55 and CB1 and 14-fold selectivity against CB2.1 Inhibits N-arachidonylglycine-induced acrosomal exocytosis in human spermatozoa indicating that GPR18 may be involved in physiological processes of human spermatozoa.2 | | Uses | PSB-CB5 is a potent and selective antagonist of GRP18. PSB-CB5 has the potential for the research of metabolic disease and obesity[1]. | | storage | Store at -20°C | | References | [1] V. REMPEL. Bicyclic imidazole-4-one derivatives: a new class of antagonists for the orphan G protein-coupled receptors GPR18 and GPR55[J]. MedChemComm, 2014, 5 1: 632-649. DOI:10.1039/c3md00394a
[2] CAROLINE FLEGEL. Characterization of non-olfactory GPCRs in human sperm with a focus on GPR18.[J]. Scientific Reports, 2016: 32255. DOI:10.1038/srep32255 |
| | PSB CB5 Preparation Products And Raw materials |
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