[3,3'-Bipyridine]-5-methanol, 2',4,6-trimethoxy-α-2-naphthalenyl-

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[3,3'-Bipyridine]-5-methanol, 2',4,6-trimethoxy-α-2-naphthalenyl- manufacturers

  • Lipoxygenin
  • Lipoxygenin pictures
  • $775.00
  • 2026-04-22
  • CAS:2247911-68-6
  • Purity:
  • Supply Ability: 10g
[3,3'-Bipyridine]-5-methanol, 2',4,6-trimethoxy-α-2-naphthalenyl- Basic information
Product Name:[3,3'-Bipyridine]-5-methanol, 2',4,6-trimethoxy-α-2-naphthalenyl-
Synonyms:[3,3'-Bipyridine]-5-methanol, 2',4,6-trimethoxy-α-2-naphthalenyl-;2′,4,6-trimethoxy-α-2-naphthalenyl-[3,3′-bipyridine]-5-methanol
CAS:2247911-68-6
MF:C24H22N2O4
MW:402.45
EINECS:
Product Categories:
Mol File:2247911-68-6.mol
[3,3'-Bipyridine]-5-methanol, 2',4,6-trimethoxy-α-2-naphthalenyl- Structure
[3,3'-Bipyridine]-5-methanol, 2',4,6-trimethoxy-α-2-naphthalenyl- Chemical Properties
Boiling point 580.5±50.0 °C(Predicted)
density 1.238±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMF: 30mg/mL,DMSO: 30mg/mL,DMSO:PBS (pH 7.2) (1:1): 0.5mg/mL
form A crystalline solid
pka11.59±0.20(Predicted)
Safety Information
MSDS Information
[3,3'-Bipyridine]-5-methanol, 2',4,6-trimethoxy-α-2-naphthalenyl- Usage And Synthesis
UsesLipoxygenin is a non-redox 5-lipoxygenase (5-LO) inhibitor with an IC50 of 5 μM. Lipoxygenin modulates the β-catenin-5-LO complex, inducing a decrease in β-catenin and 5-LO levels in the nucleus[1].
Biological ActivityLipoxygenin is an inhibitor of 5-lipoxygenase (5-LO) with an IC50 value of 5 μM for inhibition of 5-LO product synthesis in isolated human granulocytes stimulated with the cation ionophore A23187 .1 It inhibits hedgehog-dependent signaling in Shh-LIGHT2 cells and TGF-β-, activin A-, bone morphogenic protein (BMP)-, or Wnt-dependent signaling in HEK293T cells (IC50s = 9.3, 3.2, 8.2, 9.6, and 3.7 μM, respectively, in luciferase reporter assays). Lipoxygenin (5 and 10 μM) increases levels of troponin T (TnnT), a marker of cardiomyocyte differentiation, in human induced pluripotent stem cells (iPSCs) stimulated with BMP4 and the glycogen synthase kinase 3 (GSK3) inhibitor CHIR99021 .
IC 505-LO: 5 μM (IC50)
References1.Brand, S., Roy, S., Schrder, P., et al.Combined proteomic and in silico target identification reveal a role for 5-lipoxygenase in developmental signaling pathwaysCell Chem. Biol.25(9)1095-1106(2018)
[3,3'-Bipyridine]-5-methanol, 2',4,6-trimethoxy-α-2-naphthalenyl- Preparation Products And Raw materials
Tag:[3,3'-Bipyridine]-5-methanol, 2',4,6-trimethoxy-α-2-naphthalenyl-(2247911-68-6) Related Product Information
5H-[1]Benzopyrano[2,3-b]pyridin-5-ol [3,3'-Bipyridine]-5-methanol, 2',4,6-trimethoxy-α-2-naphthalenyl- Dihydrocaffeic acid TRYPTANTHRIN (-)-PINORESINOL Caffeic acid