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3-(5-Bromo-3-methyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidine-2,6-dione

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3-(5-Bromo-3-methyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidine-2,6-dione Basic information
Product Name:3-(5-Bromo-3-methyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidine-2,6-dione
Synonyms:2,6-Piperidinedione, 3-(5-bromo-2,3-dihydro-3-methyl-2-oxo-1H-benzimidazol-1-yl)-;3-(5-bromo-3-methyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidine-2,6-dione;3-(5-Bromo-3-methyl-2-oxo-2,3-dihydro-1-benzimidazolyl)piperidine-2,6-dione;3-(5-Bromo-3-methyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazole-1-yl)piperidine-2,6-dione;3-(5-Bromo-2,3-dihydro-3-methyl-2-oxo-1H-benzimidazol-1-yl)-2,6-piperidinedione (ACI);3-(5-BROMO-3-METHYL-2-OXO-2,3-DIHYDRO-1H-BENZODIMIDAZOL-1-YL)PIPERIDINE-2;3-(5-Bromo-3-methyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidine-2,6-dione , E3 ligase Ligand 32;3-(5-bromo-3-methyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidine-2,6-dione - [AC80655]
CAS:2300099-98-1
MF:C13H12BrN3O3
MW:338.16
EINECS:
Product Categories:
Mol File:2300099-98-1.mol
3-(5-Bromo-3-methyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidine-2,6-dione Structure
3-(5-Bromo-3-methyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidine-2,6-dione Chemical Properties
Boiling point 533.3±50.0 °C(Predicted)
density 1.670±0.06 g/cm3(Predicted)
storage temp. Storage temp. 2-8°C
pka11.11±0.40(Predicted)
form Solid
color Off-white to light brown
InChIInChI=1S/C13H12BrN3O3/c1-16-10-6-7(14)2-3-8(10)17(13(16)20)9-4-5-11(18)15-12(9)19/h2-3,6,9H,4-5H2,1H3,(H,15,18,19)
InChIKeyJTRNEHBIODAOTJ-UHFFFAOYSA-N
SMILESN1C(=O)CCC(N2C(=O)N(C)C3=CC(Br)=CC=C32)C1=O
Safety Information
MSDS Information
3-(5-Bromo-3-methyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidine-2,6-dione Usage And Synthesis
UsesE3 ligase Ligand 32 (First product in Example 52) is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 32 can be connected to the ligand for protein by a linker to form PROTACs and can be used for the synthesis of PROTAC SMARCA2/4-degrader-29 (HY-162743)[1].
IC 50VHL
References[1] Nan Ji, et al. Smarca degraders and uses thereof. Worldwide applications 2020 US WO
3-(5-Bromo-3-methyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidine-2,6-dione Preparation Products And Raw materials
Tag:3-(5-Bromo-3-methyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidine-2,6-dione(2300099-98-1) Related Product Information
2,6-Piperidinedione, 3-(6-bromo-2,3-dihydro-3-methyl-2-oxo-1H-benzimidazol-1-yl)- 3-(5-Bromo-6-fluoro-3-methyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidine-2,6-dione 3-(4-Bromo-3-methyl-2-oxo-2,3-dihydro-1h-benzo[d]imidazol-1-yl)piperidine-2,6-dione 2,6-Piperidinedione, 3-(6-bromo-2,3-dihydro-3-methyl-2-oxo-1H-benzimidazol-1-yl)-, (3S)- 3-[5-Bromo-2,3-dihydro-3-(1-methylethyl)-2-oxo-1H-benzimidazol-1-yl]-2,6-piperidinedione 3-(5-Bromo-4-fluoro-3-methyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidine-2,6-dione