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9,10-Dihydro-9,10[1',2']-benzenoanthracene-1,4-dione manufacturers
- INCA-6
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- $30.00
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2026-07-14
- CAS:3519-82-2
- Purity: 99.82%
- Supply Ability: 10g
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| | 9,10-Dihydro-9,10[1',2']-benzenoanthracene-1,4-dione Basic information |
| Product Name: | 9,10-Dihydro-9,10[1',2']-benzenoanthracene-1,4-dione | | Synonyms: | 1,4,9,10-Tetrahydro-9,10-[1,2]benzenoanthracene-1,4-dione;9,10-[1,2]Benzeno-1,4,9,10-tetrahydroanthracene-1,4-dione;9,10-[1,2]Benzeno-9,10-dihydro-1,4-anthraquinone;9,10-[1,2]Benzeno-9,10-dihydroanthracene-1,4-dione;9,10-Dihydro-9,10-[1,2]benzeno-1,4-anthraquinone;Nsc25996;NFAT Activation Inhibitor III;INCA-6 NFAT Activation Inhibitor III | | CAS: | 3519-82-2 | | MF: | C20H12O2 | | MW: | 284.31 | | EINECS: | | | Product Categories: | Protein Phosphatase | | Mol File: | 3519-82-2.mol | ![9,10-Dihydro-9,10[1',2']-benzenoanthracene-1,4-dione Structure](CAS/GIF/3519-82-2.gif) |
| | 9,10-Dihydro-9,10[1',2']-benzenoanthracene-1,4-dione Chemical Properties |
| Melting point | 180-181 °C(Solvent: Xylene) | | Boiling point | 464.196±45.00 °C(Press: 760.00 Torr)(predicted) | | density | 1.384±0.10 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | storage temp. | Store at RT | | solubility | Soluble in DMSO | | form | Yellow solid | | color | Light yellow to yellow | | InChI | 1S/C20H12O2/c21-15-9-10-16(22)20-18-12-6-2-1-5-11(12)17(19(15)20)13-7-3-4-8-14(13)18/h1-10,17-18H | | InChIKey | GCHPUOHXXCNSQL-UHFFFAOYSA-N | | SMILES | O=C1C2=C(C3c4c(cccc4)C2c5c3cccc5)C(=O)C=C1 |
| WGK Germany | WGK 1 | | Storage Class | 11 - Combustible Solids |
| | 9,10-Dihydro-9,10[1',2']-benzenoanthracene-1,4-dione Usage And Synthesis |
| Description | NFAT activation inhibitor III is a cell-permeant inhibitor of signaling through nuclear factor of activated T cells (NFAT). It binds the substrate recognition site of the phosphatase calcineurin (Kd = 0.8 μM), preventing it from binding and dephosphorylating NFAT. NFAT activation inhibitor III blocks the nuclear import of NFAT in T cells stimulated with ionomycin . It prevents the induced expression of cytokine mRNAs in T cells stimulated with phorbol ester and ionomycin. | | Uses | INCA 6 inhibits nuclear factor of activated T cells (NFAT) dephosphorylation and nuclear import, which in turn, interferes with downstream targets of NFAT including induction of cytokine mRNAs. | | Definition | ChEBI: LSM-2729 is an anthraquinone. | | General Description | A cell-permeable, potent, and selective inhibitor of Calcineurin-NFAT (Nuclear Factor of Activated T cells) signaling. Binds to calcineurin with high affinity (Kd = 800 nM), disrupts its interaction with NFAT, and completely blocks calcineurin-dependent NFAT dephosphorylation, nuclear import (~40 μM in C1.7W2 T cells), and induction of NFAT-targeted cytokine mRNAs. Unlike CsA (Cat. No. 239835) and FK506, INCA-6 does not affect calcineurin activity or its downstream signaling. | | Biological Activity | Inhibitor of interaction between calcineurin and its substrate nuclear factor of activated T cells (NFAT); blocks at the substrate recognition site but not at the catalytic site (K d = 0.8 mM). Inhibits NFAT dephosphorylation and nuclear import. Also prevents induction of cytokine mRNAs that are downstream targets of NFAT. | | Biochem/physiol Actions | Cell permeable: yes | | storage | Store at -20°C |
| | 9,10-Dihydro-9,10[1',2']-benzenoanthracene-1,4-dione Preparation Products And Raw materials |
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