α-CGRP (human) (trifluoroacetate salt)

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α-CGRP (human) (trifluoroacetate salt) Basic information
Product Name:α-CGRP (human) (trifluoroacetate salt)
Synonyms:α-CGRP (human) (trifluoroacetate salt)
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MW:0
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α-CGRP (human) (trifluoroacetate salt) Structure
α-CGRP (human) (trifluoroacetate salt) Chemical Properties
solubility Water: 1 mg/ml
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α-CGRP (human) (trifluoroacetate salt) Usage And Synthesis
Descriptionα-Calcitonin gene-related peptide (α-CGRP) is a neuropeptide with diverse biological activities.1 It belongs to the calcitonin family of peptides, which also includes amylin (Item No. 24274), calcitonin (Item Nos. 24409 | 24410), and adrenomedullin.2 α-CGRP binds selectively to a heteromeric complex of calcitonin receptor-like receptor (CRLR) and receptor activity-modifying protein 1 (RAMP1; IC50 = 0.1 nM) over a complex of CLCR and RAMP2 (IC50 = 1,300 nM).3 It also binds selectively to complexes of human calcitonin receptor 2 (CTR2) and RAMP1 (IC50 = 43.7 nM) compared to CTR2 and RAMP2 complexes (IC50 = 141.3 nM) in amylin radioligand displacement assays.4 α-CGRP induces cAMP-activated currents in Xenopus oocytes with endogenous Cgrp receptors that overexpress RAMP1 (EC50 = 9 nM).3 It also induces cAMP accumulation in COS-7 cells transfected with both CTR2 and RAMP1 (EC50 = 8.32 nM).4WARNING This product is not for human or veterinary use.
References[1] F A RUSSELL. Calcitonin gene-related peptide: physiology and pathophysiology.[J]. Physiological reviews, 2014, 94 4: 1099-1142. DOI: 10.1152/physrev.00034.2013
[2] WIMALAWANSA S J. Amylin, calcitonin gene-related peptide, calcitonin, and adrenomedullin: a peptide superfamily.[J]. Critical reviews in neurobiology, 1997, 11 2-3: 167-239. DOI: 10.1615/critrevneurobiol.v11.i2-3.40
[3] LINDA M. MCLATCHIE. RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor[J]. Nature, 1998, 393 6683: 333-339. DOI: 10.1038/30666
[4] MADHARA UDAWELA. Distinct receptor activity-modifying protein domains differentially modulate interaction with calcitonin receptors.[J]. Molecular Pharmacology, 2006, 69 6: 1984-1989. DOI: 10.1124/mol.105.021915
α-CGRP (human) (trifluoroacetate salt) Preparation Products And Raw materials
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