| Company Name: |
SIMAGCHEM CORP |
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+86-5922680277 +86-13806087780 |
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- Timegadine
-
- $1520.00
-
2026-04-21
- CAS:71079-19-1
- Purity:
- Supply Ability: 10g
- Timegadine
-
- $1520.00
-
2025-07-17
- CAS:71079-19-1
- Purity:
- Supply Ability: 10g
|
| | Timegadine Basic information |
| Product Name: | Timegadine | | Synonyms: | Timegadine;N-Cyclohexyl-N'-(2-methyl-4-quinolyl)-N''-(2-thiazolyl)guanidine;N-Cyclohexyl-N''-(2-methylquinol-4-yl)-N'-2-thiazolylguanidine;SR1368;Guanidine, N-cyclohexyl-N'-(2-methyl-4-quinolinyl)-N''-2-thiazolyl- | | CAS: | 71079-19-1 | | MF: | C20H23N5S | | MW: | 365.49 | | EINECS: | 2751840 | | Product Categories: | | | Mol File: | 71079-19-1.mol |  |
| | Timegadine Chemical Properties |
| Boiling point | 550.8±52.0 °C(Predicted) | | density | 1.31±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | pka | 7.71±0.50(Predicted) |
| | Timegadine Usage And Synthesis |
| Uses | Timegadine, is an antiinflammatory drug, that has shown to act as prostaglandin synthetase inhibitor which also inhibits cyclo-oxygenase (COX) and lipo-oxygenase. | | in vivo | Timegadine, a new antiinflammatory agent, is found to be a potent, competitive inhibitor of prostaglandin synthetase which also inhibits cyclo-oxygenase (COX) and lipoxygenase. Daily oral doses of 10 to 30 mg/kg of Timegadine significantly inhibit both the primary and secondary lesions of adjuvant arthritis when the treatment is initiated on the day of the disease induction and continues for 28 days. Timegadine is able specifically to prevent the development of the swelling of the non-injected paw until 28 days after the adjuvant injection when administered for 5 days prior to and 5 days after the induction of the disease, in analogy with the effect of cyclophosphamide[1]. | | IC 50 | COX: 5 nM (IC50, in rabbit platelets); COX: 20 μM (IC50, in rat brain); lipo-oxygenase: 100 μM (IC50, in horse and washed rabbit platelets) |
| | Timegadine Preparation Products And Raw materials |
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