| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:Isonixin
CAS:57021-61-1
Package:25mg/RMB 10600;100mg/RMB 17500;50mg/RMB 13800
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isonixin manufacturers
- Isonixin
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- $1520.00
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2026-05-11
- CAS:57021-61-1
- Purity:
- Supply Ability: 10g
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| | isonixin Basic information |
| Product Name: | isonixin | | Synonyms: | isonixin;Isonixine;1,2-Dihydro-2-oxo-N-(2,6-xylyl)-3-pyridinecarboxamide;N-(2,6-Dimethylphenyl)-1,2-dihydro-2-oxo-3-pyridinecarboxamide;Nixyn;Nixyn hermes;3-Pyridinecarboxamide, N-(2,6-dimethylphenyl)-1,2-dihydro-2-oxo- | | CAS: | 57021-61-1 | | MF: | C14H14N2O2 | | MW: | 242.277 | | EINECS: | 2605216 | | Product Categories: | | | Mol File: | 57021-61-1.mol |  |
| | isonixin Chemical Properties |
| Melting point | 266-267° | | Boiling point | 370.08°C (rough estimate) | | density | 1.1087 (rough estimate) | | refractive index | 1.5300 (estimate) | | pka | 10.21±0.10(Predicted) |
| Toxicity | LD50 in male, female mice, male, female rats (mg/kg): 7000, 8000, >6000, >6000 orally; all >2000 i.p. (Cadena) |
| | isonixin Usage And Synthesis |
| Uses | Isonixin (Isonixine) is a non-steroidal compound. Isonixin can be used for the research of pain and inflammation[1][2][3][4]. | | Definition | ChEBI: Isonixin is an aromatic amide. | | in vivo | Isonixine potentiates hexobarbital sleep time, reduces motor activity, antagonizes cardiazol-induced convulsions, causes hyperthermia, and inhibits tremorine-induced trembling in mice[1].
Isonixine (p.o.) showes a 3.15 h half-life of absorption and rapidly absorbs in a gastro-intestinal tract[2].
Isonixine (i.v., intragastrically and intraduodenally) mainly excrets via urine, and isonixine can be eliminated by urine within 50 hours[3].
Isonixine (2000 mg/kg; p.o. once daily for 6 months) presents some mild toxic effects and induces no gastrointestinal lesion in male rabbits and rats[4]. | | References | [1] Mitjavila MT, Martorell M. Algunos efectos de la isonixina sobre el sistema nervioso central [Various effects of isonixine on the central nervous system]. Arch Farmacol Toxicol. 1979 Dec;5(3):183-4. PMID:317574
[2] Carrera G, et al. Studies of absorption, distribution and excretion of 2,6-xylidide of 2-pyridone-3-carboxylic acid (isonixine). Arzneimittelforschung. 1979;29(9):1401-4. PMID:583249
[3] Carrera G, et al. Etude pharmacocinétique de l'isonixine [Pharmacokinetic study of isonixine]. Arch Farmacol Toxicol. 1978 Apr;4(1):111-2. PMID:697374
[4] Mitjavila MT, et al. Toxicological investigations of isonixine. Arzneimittelforschung. 1977 Jul;27(7):1460-4. PMID:578473 |
| | isonixin Preparation Products And Raw materials |
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