2-[2-(dimethylamino)ethoxy]-N-tricyclo[3.3.1.13,7]dec-1-ylacetamide monohydrochloride
| 中文名称 | 2-[2-(dimethylamino)ethoxy]-N-tricyclo[3.3.1.13,7]dec-1-ylacetamide monohydrochloride |
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| 中文同义词 | 盐酸曲金刚胺;化合物 T13209L;化合物 TROMANTADINE HYDROCHLORIDE |
| 英文名称 | 2-[2-(dimethylamino)ethoxy]-N-tricyclo[3.3.1.13,7]dec-1-ylacetamide monohydrochloride |
| 英文同义词 | 2-[2-(dimethylamino)ethoxy]-N-tricyclo[3.3.1.13,7]dec-1-ylacetamide monohydrochloride;Einecs 255-434-5;Tromantadin hydrochlorid;Tromantadine HCl;Virumerz;Viru-merz;Viruserol |
| CAS号 | 41544-24-5 |
| 分子式 | C16H28N2O2.ClH |
| 分子量 | 316.86666 |
| EINECS号 | 2554345 |
| 相关类别 | |
| Mol文件 | 41544-24-5.mol |
| 结构式 | ![2-[2-(dimethylamino)ethoxy]-N-tricyclo[3.3.1.13,7]dec-1-ylacetamide monohydrochloride 结构式](CAS/20180906/GIF/41544-24-5.gif) |
2-[2-(dimethylamino)ethoxy]-N-tricyclo[3.3.1.13,7]dec-1-ylacetamide monohydrochloride 性质
| 熔点 | 157-158° |
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| 形态 | 固体 |
| 颜色 | 白色至米白色 |
Tromantadine hydrochloride，Amantadine 衍生物，具有抗疱疹活性，可抑制单纯疱疹病毒1型 (HSV-1) 和 HSV-2 的复制。
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HSV-1
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HSV-2
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Treatment of the cells with 10 to 50μg of Tromantadine reduces HSV-induced cytopathic effect. Treatment with 100 to 500μg of Tromantadine inhibits herpes simplex virus-induced cytopathic effect and reduces virus production. Complete inhibition of virus production is observed with treatments of 500μg to 1 mg. The antiherpetic activity of Tromantadine is dependent upon the viral inoculum size and the time of addition of the compound with respect to infection.
安全信息
| 毒性 | LD50 orally in rats: 630 mg/kg; i.v. in mice: 71.0 mg/kg (Peteri, Sterner) |
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