VU0400195 manufacturers
- VU0400195
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- $1980.00
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2026-05-11
- CAS:1309434-83-0
- Purity:
- Supply Ability: 10g
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| | VU0400195 Basic information |
| Product Name: | VU0400195 | | Synonyms: | VU0400195;ML 182;ML182;ML-182;2-Pyridinecarboxamide, N-[3-chloro-4-[(3aR,4S,7R,7aS)-1,3,3a,4,7,7a-hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]phenyl]- | | CAS: | 1309434-83-0 | | MF: | C21H16ClN3O3 | | MW: | 393.82 | | EINECS: | | | Product Categories: | | | Mol File: | 1309434-83-0.mol |  |
| | VU0400195 Chemical Properties |
| Boiling point | 583.0±50.0 °C(Predicted) | | density | 1.485±0.06 g/cm3(Predicted) | | pka | 10.72±0.70(Predicted) |
| | VU0400195 Usage And Synthesis |
| Description | VU0400195 is a novel positive allosteric modulator of the metabotropic glutamate receptor 4 (mGlu(4)) with oral efficacy in an antiparkinsonian animal model. | | Uses | VU0400195 (ML182) is a oral active and allosteric modulator of the metabotropic glutamate receptor 4 (mGlu4) with the EC50 of 291 nM. VU0400195 can be used for study of antiparkinsonian animal model[1][2]. | | IC 50 | hmGluR4a: 291 nM (EC50) | | References | [1] Jones CK, et al. Discovery, synthesis, and structure-activity relationship development of a series of N-4-(2,5-dioxopyrrolidin-1-yl)phenylpicolinamides (VU0400195, ML182): characterization of a novel positive allosteric modulator of the metabotropic glutamate receptor 4 (mGlu(4)) with oral efficacy in an antiparkinsonian animal model. J Med Chem. 2011 Nov 10;54(21):7639-47. DOI:10.1021/jm200956q
[2] Darren W. Engers, et al. Discovery, Synthesis, and Preclinical Characterization of N-(3-Chloro-4-fluorophenyl)-1H-pyrazolo[4,3-b]pyridin-3-amine (VU0418506), a Novel Positive Allosteric Modulator of the Metabotropic Glutamate Receptor 4 (mGlu4). ACS Chem. Neurosci. 2016, 7, 9, 1192–1200. |
| | VU0400195 Preparation Products And Raw materials |
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