5'-Guanidinonaltrindole di(trifluoroacetate) salt hydrate

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Products Intro: Product Name:GNTI TFA
CAS:219655-57-9
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Products Intro: Product Name:5′-Guanidinonaltrindole di(trifluoroacetate) salt hydrate
CAS:219655-57-9
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Products Intro: Product Name:5′-Guanidinonaltrindole di(trifluoroacetate)
CAS:219655-57-9
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Products Intro: Product Name:5-Guanidinonaltrindole di(trifluoroacetate) Salt Hydrate
CAS:219655-57-9
5'-Guanidinonaltrindole di(trifluoroacetate) salt hydrate Basic information
Product Name:5'-Guanidinonaltrindole di(trifluoroacetate) salt hydrate
Synonyms:5'guanidinonaltrindole bis(trifluoroacetate);5μ-Guanidinonaltrindole hydrate di(trifluoroacetate) salt;5′-Guanidinonaltrindole di(trifluoroacetate) salt hydrate;5'-Guanidinonaltrindole di(trifluoroacetate)
CAS:219655-57-9
MF:C27H29N5O3
MW:471.558
EINECS:
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Mol File:219655-57-9.mol
5'-Guanidinonaltrindole di(trifluoroacetate) salt hydrate Structure
5'-Guanidinonaltrindole di(trifluoroacetate) salt hydrate Chemical Properties
storage temp. 2-8°C
solubility H2O: soluble30mg/mL
form solid
Water Solubility H2O: 30mg/mL
Safety Information
WGK Germany 3
Storage Class11 - Combustible Solids
MSDS Information
5'-Guanidinonaltrindole di(trifluoroacetate) salt hydrate Usage And Synthesis
Uses5′-Guanidinonaltrindole di(trifluoroacetate) Salt is a selective opioid receptor antagonist. It has also been utilized to develop fluorescent methods to identify phosphopantetheinyl transferase inhibitors.
Uses5′-Guanidinonaltrindole di(trifluoroacetate) salt hydrate (GNTI) has been used as a selective κ opioid receptor antagonist:
  • to study the influence of opioid receptor types on the anti-hyperalgesic effect of dipeptidyl peptidase 4 (DPP4) inhibitors in inflammation
  • to study the role of κ opioid receptor in the forebrain-dependent associative task, Whisker-Trace Eyeblink conditioning (WTEB)
  • to validate its inhibitory actions on Akt kinase activities

Biochem/physiol Actions5′-Guanidinonaltrindole di(trifluoroacetate) (GNTI) is a 5‘-guanidine derivative and a selective κ opiate receptor antagonist. It is five-fold more potent and 500-fold more selective than norbinaltorphimine (nor-BNI) for the κ opioid receptor in smooth muscle preparations.
5'-Guanidinonaltrindole di(trifluoroacetate) salt hydrate Preparation Products And Raw materials
Tag:5'-Guanidinonaltrindole di(trifluoroacetate) salt hydrate(219655-57-9) Related Product Information
GNTI TFA 5'-Guanidinonaltrindole di(trifluoroacetate) salt hydrate 2,3,4,9-TETRAHYDRO-1H-CARBAZOL-1-OL Naltrindol ETHYL 6-TERT-BUTYL-2-METHYLNICOTINATE