2024 年，复旦大学李敏团队在《Angewandte Chemie》发表研究，利用手性磷酸催化的不对称环加成反应，高效构建了一系列具有生物活性的手性吡咯烷衍生物，该方法对映选择性高达 98% ee，且反应条件温和，为新型药物中间体的合成提供了高效路径。
针对这类前沿需求，百灵威推出针对性产品系列。手性磷酸催化剂系列，可适配多种不对称环加成反应；手性胺类试剂，在不对称亲核取代反应中能精准控制立体化学；此外，还有手性恶唑类辅基，为底物的不对称修饰提供稳定导向，满足科研与生产中不同不对称合成场景的需求。
手性催化剂和配体
| 品名 | CAS | 货号 | 1,2-Bis((2R,5R)-2,5-di-i-propylphospholano)ethane, 96%
1,2-二（（2R，5R）-2,5-二异丙基磷酸）乙烷
136705-63-0
2,6-Bis[(4S)-4-tert-butyloxazolin-2-yl]pyridine, 98%, ee: ≥99%
2,6-双[(4S)-4-叔丁基-2-恶唑啉基]吡啶
118949-63-6
(3aR,3'aR,8aS,8'a'S)-2,2'-Cyclopropylidenebis[3a,8a-dihydro-8H-Indeno[[1,2-d]oxazole], 98%
(3aR,3'aR,8aS,8'a'S)-2,2'-环丙亚基双[3a,8a-二氢-8H-茚并[[1,2-d]恶唑]
229184-98-9
1,3-Bis((S)-4-phenyl-4,5-dihydrooxazol-2-yl)benzene, 98%, ee: ≥99%
1,3-双((S)-4-苯基-4,5-二氢恶唑-2-基)苯
876953-19-4
(4S,4'S)-2,2'-Cyclohexylidenebis[4,5-dihydro-4-(phenylmethyl)oxazole], 97%, ee: 98%
(4S,4'S)-2,2'-环己亚基双[4,5-二氢-4-苯甲基噁唑]
1003886-07-4
(S)-(+)-2-[2-(Diphenylphosphino)phenyl]-4-phenyl-2-oxazoline, 97%
(S)-(+)-2-[2-(二苯基膦)苯基]-4-苯基-2-噁唑啉
148461-15-8
(R)-(+)-3,3'-Bis(3,5-bis(trifluoromethyl)phenyl)-1,1'-bi-2,2'-naphthol, 95%
(R)-(+)-3,3'-双(3,5-双(三氟甲基)苯基)-1,1'-联萘-2,2'-二酚
756491-54-0
9-Amino-(9-deoxy)epi-quinine trihydrochloride, 98%
9-氨基-(9-脱氧)表奎宁 三盐酸盐
1231763-32-8
(R)-2,2''-Bis(bromomethyl)-1,1''-binaphthalene, 97%, ee: 98%
(R)-2,2''-双(溴甲基)-1,1''-双萘
86631-56-3
(S)-2,2'-Bis(bromomethyl)-1,1'-binaphthalene, 97%, ee: 98%
(S)-2,2'-二(溴甲基)-1,1'-联萘
37803-02-4
(R)-(+)-5,5'-Bis(diphenylphosphino)-4,4'-bi-1,3-benzodioxole, min. 98% (R)-(+)-SEGPHOS
5,5'-双(二苯基磷酰)-4,4'-二-1,3-联苯
244261-66-3
1-[(4S)-4,5-Dihydro-4-isopropyl-2-oxazolyl]isoquinoline, 97%, ee: 98%
1-[(4S)-4,5-二氢-4-异丙基-2-噁唑基]异喹啉
1701405-00-6
手性还原试剂
| 品名 | CAS | 货号 | (-)-B-Chlorodiisopinocampheylborane, 60 wt.% solution in heptane, ca.1.7 M, J&KSeal
(-)-B-氯代二异松香芹硼烷
85116-37-6
(S)-(-)-2-Methyl-CBS-oxazaborolidine, 1.0 M solution in THF
(S)-(-)-2-甲基-CBS-噁唑硼烷
112022-81-8
(R)-2-Methyl-CBS-oxazaborolidine, 97%
(R)-2-甲基-CBS-恶唑硼烷
112022-83-0
手性分析
| 品名 | CAS | 货号 | (S)-(-)-1-Phenylethanol, 99%, reagent grade
(S)-(-)-1-苯基乙醇
1445-91-6
(R)-(+)-1-Methylbenzyl isocyanate, 98%
(R)-(+)-1-甲基苄基异氰酸酯
33375-06-3
(S)-(-)-1-Phenyl-1-propanol, 98%, ee: 90%
(S)-(-)-1-苯基-1-丙醇
613-87-6
手性辅基、试剂及拆分试剂
| 品名 | CAS | 货号 | (2R)-Bornane-10,2-sultam, 98%
(2R)-莰烷-10,2-磺内酰胺
94594-90-8
(S)-(-)-N,α-Dimethylbenzylamine, 98%
(S)-(-)-N,α-二甲基苯甲基胺
19131-99-8
(R)-(+)-1-(4-Bromophenyl)ethylamine, 98%
(R)-(+)-1-(4-溴苯基)乙胺
45791-36-4
(-)-Camphanic acid chloride, 98%, reagent grade
(-)-氯代樟脑酸
39637-74-6
手性砌块
| 品名 | CAS | 货号 | (2S,3S)-(+)-2,3-Butanediol, 98%, for synthesis
(2S,3S)-(+)-2,3-丁二醇
19132-06-0
(S)-(+)-2-Amino-1-propanol, 98%
(S)-(+)-2-氨基-1-丙醇
2749-11-3
(S)-(-)-2-(Aminomethyl)-1-ethylpyrrolidine, 97%
(S)-(-)-2-(氨甲基)-1-乙基吡咯烷
22795-99-9
有机金属试剂
| 品名 | CAS | 货号 | Phenylmagnesium bromide, 2.5 M solution in diethyl ether, J&KSeal
溴化苯基镁
100-58-3
Isobutylmagnesium bromide, 1.0 M solution in THF, J&Kseal
异丁基溴化镁
926-62-5
4-Chlorophenylmagnesium bromide, 1.0 M solution in 2-MeTHF, J&Kseal
4-氯苯基溴化镁
873-77-8
Methylmagnesium iodide, 3.0 M solution in diethyl ether, J&Kseal,Clear to dark brown
甲基碘化镁
917-64-6
Hexylmagnesium bromide, 0.8 M solution in THF, J&KSeal
己基溴化镁
3761-92-0
Ethylmagnesium bromide, 1.0 M solution in tert-butyl methyl ether, J&KSeal
乙基溴化镁
925-90-6
合成试剂
| 品名 | CAS | 货号 | Titanium(IV) isopropoxide, 98%
钛酸四异丙酯(IV)
546-68-9
合成溶剂
| 品名 | CAS | 货号 | Butyl acetate, 99%, SuperDry, J&KSeal
乙酸正丁酯
123-86-4
Cyclopentane, 98%, SuperDry, J&KSeal
环戊烷
287-92-3
Xylenes, 99%, SuperDry, mixture of isomers, J&KSeal
二甲苯
1330-20-7
1,2-Dichloroethane, 99.5%, SuperDry, with molecular sieves, water≤30ppm, J&KSeal
1,2-二氯乙烷
107-06-2
相关耗材
| 品名 | CAS | 货号 | Wooden test tube clamp
木试管夹
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智慧实验室
| 品名 | CAS | 货号 | Smart Hazardous Chemical Management Cabinet HCEF00, Full cabinet size: 900 * 500 * 1980mm, internal size: 650 * 420 * 1550mm, volume 423L
RFID自净化防火柜HCEF-400
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Bio-Vanguard
| 品名 | CAS | 货号 | Antibacterial 100% Cotton laboratory coats, men, XXL (≥180 cm, ≥80 kg), long-sleeved
抗菌纯棉实验服
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