关键词：地司特泰，双通道工具肽，Disitertide，272105-42-7，多肽定制合成，多肽厂家
Product Name（产品名称）：Disitertide（P144）
Synonyms（别称）：地司特泰
CAS No.：272105-42-7
Catalog No（目录编号）：GT-P2595
Brand（产地）：Go Top peptide（杭州固拓）
Description（描述）：Disitertide（P144）是一种人工合成的14氨基酸多肽抑制剂，其与TGF-β1高亲和结合，阻断其与TβRII/TβRI受体复合物形成→抑制Smad2/3磷酸化及后续促纤维化、促转移基因表达；在100µg/mL水平可下调PI3K和p-Akt蛋白水平，并上调Bax→诱导凋亡与失巢凋亡；但该作用为间接功能性抑制，尚无直接激酶IC50数据；同时干预TGF-β/Smad与PI3K/Akt/mTOR两条通路，因此在抗纤维化、抗肿瘤及抗瘢痕研究中具有“双通路”协同标签。总结来说Disitertide是一种多靶点多肽抑制剂，主要通过阻断TGF-β1信号通路发挥作用，兼具PI3K抑制和促凋亡效应。Disitertide已被官方化学品数据库列为TGF-β1多肽抑制剂，其在抗纤维化、抗疤痕、抗肿瘤干细胞与耐药性等方面展现出良好的研究前景，目前主要用于科研实验，尚未进入临床广泛应用。
Disitertide (P144) is a synthetic 14-amino-acid peptide inhibitor that binds with high affinity to TGF-β1, blocking its interaction with the TβRII/TβRI receptor complex, thereby inhibiting Smad2/3 phosphorylation and subsequent pro-fibrotic and pro-metastatic gene expression. At a concentration of 100 µg/mL, it can downregulate PI3K and p-Akt protein levels and upregulate Bax, inducing apoptosis and anoikis. However, this effect is an indirect functional inhibition, and no direct kinase IC50 data is available. Moreover, it intervenes in both the TGF-β/Smad and PI3K/Akt/mTOR pathways, giving it a "dual-pathway" synergistic profile in anti-fibrosis, anti-tumor, and anti-scar research. In summary, Disitertide is a multi-target peptide inhibitor that primarily acts by blocking the TGF-β1 signaling pathway while also exhibiting PI3K inhibition and pro-apoptotic effects. Disitertide has been listed in official chemical databases as a TGF-β1 peptide inhibitor and shows promising research potential in anti-fibrosis, anti-scar formation, anti-tumor stem cells, and drug resistance studies. Currently, it is mainly used in scientific research and has not yet been widely applied in clinical practice.
Purity (HPLC) ≥98.0%
Single impurity≤2%
Peptide content≥75.0%
Amino Acid Composition≤±15%
Bacterial Endotoxins≤50EU/mg
Solubility（溶解）：H2O/DMSO
Packaging（包装）：用铝箔袋或透明袋真空包装。可以根据您的要求包装各种重量。Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.
Storage（储存）：阴凉干燥处（存放于-20°C，避光）Cool dry place( Store at -20°C, away from the light)
Remark（备注）:For Research Use Only. Not for human use.
申明：产品仅供科研使用，不得用于人体。
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