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中文简介｜Chinese Profile
产品名称：橙皮苷（橙皮甙）Hesperidin
品牌/供应商：长沙上禾生物科技有限公司（Changsha Staherb Natural Ingredients Co., Ltd. / Staherb®）
化学名称：橙皮素-7-芸香糖苷；7-芸香糖苷-3′,5-二羟基-4′-甲氧基黄烷酮（Hesperetin 7-rutinoside）
植物来源：芸香科柑橘属植物（甜橙 Citrus sinensis、柠檬 Citrus limon、酸橙 Citrus aurantium 等）的果皮、白络及近成熟果皮，亦为枳实、陈皮等中药的质控黄酮标志物之一
CAS：520-26-3｜分子式：C₂₈H₃₄O₁₅｜分子量：610.56｜EINECS：208-288-1
规格：90% / 92% / 95% / 98% / 99%（HPLC，可定制微粉化/DC 级）
外观：类白色至淡黄色精细粉末，无臭无味；微溶于水，易溶于稀碱、吡啶、DMF、DMSO
主要活性成分定位
橙皮苷是柑橘类植物中含量最高的黄烷酮糖苷（dihydroflavonoid glycoside），也是传统“维生素 P”复合物核心成员。其苷元为橙皮素（Hesperetin），糖基为芸香糖（鼠李糖-葡萄糖二糖），整体表现为弱酸性多酚。
核心活性概览
血管保护（维生素 P 样作用）：降低毛细血管脆性、增强管壁韧性、维持正常渗透压，改善微循环——是其在静脉功能不全、痔疮、视网膜/牙龈出血类配方中的主轴活性。
抗氧化：清除氧自由基、上调 Nrf2/ARE 通路及 SOD/GSH 等内源抗氧化酶，拮抗脂质过氧化（UV 致皮肤损伤、肝脂质过氧化等）。
抗炎与抗过敏：抑制 TNF-α、IL-6、组胺释放及相关信号通路，减轻过敏反应与慢性炎症。
调脂降糖与代谢支持：辅助降总胆固醇/LDL、升 HDL，改善胰岛素敏感性，减轻脂肪肝及药物/酒精肝损伤。
皮肤与美容协同：与 VC 协同促胶原合成、抑制酪氨酸酶与黑素生成，用于抗光老化和红血丝护理。
其他研究活性：抗菌、抗病毒、抗肿瘤先导研究、与地奥司明（Diosmin）配伍用于欧洲静脉疾病制剂。
⚠️ 原料页合规边界：Staherb 作为植提单体供应商，页面宜写“flavonoid active ingredient for formulation / R&D”，不要直接宣称“治疗高血压/痔疮/癌症”；口服生物利用度低、常需微粉化或转化为橙皮素/地奥司明前体这一药代特点可写进 Technical 段，但不进功效宣称。
English Profile｜英文简介
Product: Hesperidin (also spelled Hesperidin, Orange Peel Flavonoid)
Brand/Supplier: Changsha Staherb Natural Ingredients Co., Ltd. (Staherb®)
Chemical Name: Hesperetin 7-rutinoside; 7-Rutinoside-3′,5-dihydroxy-4′-methoxyflavanone
Botanical Source: Peel, pith and near-mature pericarp of Rutaceae citrus species — Citrus sinensis, Citrus limon, Citrus aurantium; also a marker flavonoid in Aurantii Fructus (枳实) and Citri Reticulatae Pericarpium (陈皮).
CAS: 520-26-3｜Formula: C₂₈H₃₄O₁₅｜MW: 610.56｜EINECS: 208-288-1
Spec: 90% / 92% / 95% / 98% / 99% HPLC (micronized & DC grades available)
Appearance: Off-white to pale-yellow fine powder, odorless, tasteless; very slightly soluble in water, soluble in dilute alkali, pyridine, DMF, DMSO.
Active Component Positioning
Hesperidin is the most abundant flavanone glycoside in citrus and a principal constituent of the classic “Vitamin P” bioflavonoid complex. It consists of the aglycone hesperetin linked to a rutinose (rhamnose-glucose) disaccharide, behaving as a weak-acid polyphenol.
Core Activities (non-clinical summary)
Vasoprotective (Vitamin-P like): Reduces capillary fragility, reinforces vascular wall elasticity, normalizes microcirculation — underpinning its use in venous-insufficiency, hemorrhoid and retinopathy-related formulations.
Antioxidant: Scavenges oxygen radicals, activates Nrf2/ARE pathway and endogenous enzymes (SOD, GSH), suppresses lipid peroxidation in skin and liver models.
Anti-inflammatory & antiallergic: Down-regulates TNF-α, IL-6, histamine release and related signaling.
Lipid/glucose metabolism support: Helps lower TC/LDL, raise HDL, improve insulin sensitivity, alleviate fatty liver and chemically/alcohol-induced hepatic injury.
Cosmetic synergy: With VC promotes collagen synthesis, inhibits tyrosinase/melanogenesis; used in anti-photoaging and anti-redness skincare.
Other research activities: Antibacterial, antiviral, antitumor-lead studies; converted to diosmin or neohesperidin dihydrochalcone in downstream API/food-tech use.
Formulation note: Poor aqueous solubility and low oral bioavailability drive common upgrades — micronization, hesperetin liberation, or co-formulation with diosmin; Staherb supplies both standard and micronized grades for tablet, capsule, beverage and topical use.
公司官网 http://www.staherb.com/ 资质:HALAL, KOSHER等认证
☎：19573130018 杨经理（微信同号）