链接：https://www.abinscience.cn/product/40/4315.html

名称：Anti-Human CD16a/FCGR3A Antibody (NM3E2)

货号：HY386207

种属反应性：Human

宿主：Human

形式：Liquid

纯度：>95% as determined by SDS-PAGE.

克隆性：Monoclonal

同种型：IgG1, kappa

应用：FCM

Accession号：P08637

靶点：CD16a,  CD16A, FCGR3A, Fc-gamma RIII-alpha, FcRIIIa, IgG Fc receptor III-2, Low  affinity immunoglobulin gamma Fc region receptor III-A, IGFR3, CD16a  antigen, Fc-gamma RIII, FCGR3, Fc-gamma RIIIa, FCG3, FcRIII, FcR-10

用途范围：仅用于科研

储存：Use  a manual defrost freezer and avoid repeated freeze-thaw cycles. Store  at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C  long term.

产品介绍：Anti-Human  CD16a/FCGR3A Antibody (NM3E2)  是abinScience推出的高特异性人源单克隆抗体。该抗体靶向人CD16a（FcγRIIIa），这是一种在自然杀伤（NK）细胞、巨噬细胞和中性粒细胞上表达的关键免疫球蛋白Fc段受体，参与抗体依赖性细胞介导的细胞毒性（ADCC）等免疫反应。本品克隆号为NM3E2，采用Protein A/G从细胞培养上清中纯化，纯度超过95%，经严格验证适用于流式细胞术（FCM），是研究免疫细胞分型、功能及相关疾病机制的理想工具。其高亲和力与低批间差异，为免疫学和肿瘤免疫治疗研究提供了可靠、一致的数据保障。

产品购买联系方式：027-87433958/17302791434

邮箱：info@abinscience.com

参考文献：

CD16A Shedding Regulates Innate Cell Engager-Induced Serial Killing by Natural Killer Cells. PMID: 41116262

High-affinity CD16A polymorphism associated with reduced risk ofsevere COVID-19. PMID: 40402577

Role  of ADAM17 as a regulatory checkpoint of CD16A in NK cells and as a  potential target for cancer immunotherapy. PMID: 30786043

CD16a pairs form the basal molecular subunit for the NK-cell ADCC lytic synapse. PMID: 40570099

Targeting  CD16A on NK cells and GPC3 in hepatocellular carcinoma: development and  functional validation of a therapeutic bispecific antibody. PMID:  40574860

The  novel CD16A/anti-CD3 bifunctional protein, eCD16A/anti-CD3-BFP,  redirects T cell cytotoxicity toward antibody-bound target cells. PMID:  39763374

Evidence for CD16a-Mediated NK Cell Stimulation in Antibody-Mediated Kidney Transplant Rejection. PMID: 27906829

CD16A Activation of NK Cells Promotes NK Cell Proliferation and Memory-Like Cytotoxicity against Cancer Cells. PMID: 29514797

Enhanced  IL-15-mediated NK cell activation and proliferation by an ADAM17  function-blocking antibody involves CD16A, CD137, and accessory cells.  PMID: 39053944

Fc Effector Function Contributes to the Activity of Human Anti-CTLA-4 Antibodies. PMID: 29576375

The  "less-is-more" in therapeutic antibodies: Afucosylated anti-cancer  antibodies with enhanced antibody-dependent cellular cytotoxicity. PMID:  29733746

FcγR Binding and ADCC Activity of Human IgG Allotypes. PMID: 32435243

FCGR3A 158V/F polymorphism and response to frontline R-CHOP therapy in diffuse large B-cell lymphoma. PMID: 25050883

Association  between functional FCGR3A F158V and FCGR2A R131H polymorphisms and  responsiveness to rituximab in patients with autoimmune diseases: a  meta-analysis. PMID: 37149714

Association  between the functional FCGR3A F158V and FCGR2A R131H polymorphisms and  responsiveness to biologics in rheumatoid arthritis patients: A  meta-analysis. PMID: 37114884

Polymorphism of FCGR3A gene in chronic beryllium disease. PMID: 30245507

FCGR3A/2A  polymorphisms and diffuse large B-cell lymphoma outcome treated with  immunochemotherapy: a meta-analysis on 1134 patients from two  prospective cohorts. PMID: 27282998

Inebilizumab reduces neuromyelitis optica spectrum disorder risk independent of FCGR3A polymorphism. PMID: 37804003

Functional  FCGR3A 158 V/F and IL-6 -174 C/G polymorphisms predict response to  biologic therapy in patients with rheumatoid arthritis: a meta-analysis.  PMID: 24728031

FCGR2A, FCGR3A, FCGR3B polymorphisms and susceptibility to rheumatoid arthritis: a meta-analysis. PMID: 26314337

FCGR3A F158V alleles frequency differs in multiple myeloma patients from healthy population. PMID: 39175948

FCGR3A V158F gene polymorphism and trastuzumab response in HER2-positive breast cancer patients. PMID: 39472454

FCGR2A,  FCGR3A polymorphisms and therapeutic efficacy of anti-EGFR monoclonal  antibody in metastatic colorectal cancer. PMID: 26363448

The  FCGR3A polymorphism predicts the response to rituximab-based therapy in  patients with non-Hodgkin lymphoma: a meta-analysis. PMID: 27431582

Associations  between FCGR2A rs1801274, FCGR3A rs396991, FCGR3B NA1/NA2 polymorphisms  and periodontitis: a meta-analysis. PMID: 23649770

FCGR3A  gene duplication, FcgammaRIIb-232TT and FcgammaRIIIb-HNA1a associate  with an increased risk of vertical acquisition of HIV-1. PMID: 36084039

FCGR3A  and FCGR2A Genotypes Differentially Impact Allograft Rejection and  Patients' Survival After Lung Transplant. PMID: 31249568

FCGR3A-V158F  gene polymorphism: A potential predictor for rituximab dosing  optimization in Chinese patients with neuromyelitis optica spectrum  disorder. PMID: 38579568

Associations  between functional FCGR2A R131H and FCGR3A F158V polymorphisms and  responsiveness to TNF blockers in spondyloarthropathy, psoriasis and  Crohn's disease: a meta-analysis. PMID: 27490376

The  "less-is-more" in therapeutic antibodies: Afucosylated anti-cancer  antibodies with enhanced antibody-dependent cellular cytotoxicity. PMID:  29733746

FcγR Binding and ADCC Activity of Human IgG Allotypes. PMID: 32435243

Dissection  of the FCGR3A association with RA: increased association in men and  with autoantibody positive disease. PMID: 19700393

Analysis  of FCGR3A-p.176Val variants in women with recurrent pregnancy loss and  the association with CD16a expression and anti-HLA antibody status.  PMID: 36997584

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