产品属性：
产品名称 | 规格 | CAS号 | 型号 |
Eugenol | 20mg 100mg | 97-53-0 | EY-Y0165320 |
Cas No.97-53-0
别名
化学名 4-allyl-2-methoxyphenol
分子式 C10H12O2
分子量 164.2
溶解度 Soluble in DMSO
储存条件 Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述：
Eugenol, a phenylpropanoid class compounds, is a colourless to pale yellow oily liquid extracted from certain essential oils, such as clove oil, cinnamon, nutmeg, basil and bay leaf.
In vitro: Previous study showed that eugenol could deplete intracellular GSH, inhibit GJIC and ROS generation, and had a modest effect on MMP at concentrations of 10 to 100 μM. Eugenol at high concentrations was also able to affecte [Ca2+i, PMP, as well as nd pH. The earliest and most potent effects of either was found on GSH levels and GJIC. In addition, the coadministration of glutathione ethyl ester enhanced intracellular GSH levels by almost 100% and protected cells from cell death caused by eugenol completely. Such results indicated that eugenol exhibited its hepatotoxic effects mainly via depletion of cytoprotective thiols and disruptioin in thiol-dependent processes [1].
In vivo: Animal study showed that the pretreatment with a single dose of eugenol that was 1 h before indomethacin administration was fond to cause significant reductions in gastric acid outputs, gastric mucosal lesions, as well as pepsin activity with a obvioius increase in mucin concentration. In addition, eugenol could also attenuate the elevations in gastric mucosal malondialdehyde and total nitrite significantly [2].
Clinical trial: Clinical study has been conducted to evaluate the effects of zinc oxide eugenol and metapex in root canal treatment of primary teeth. Results showed that both zinc oxide eugenol and metapex had encouraging results, however, metapex could be more safely used whenever there was a doubt about the patient's follow-up return [3].
References:
[1] Thompson DC,Barhoumi R,Burghardt RC. Comparative toxicity of eugenol and its quinone methide metabolite in cultured liver cells using kinetic fluorescence bioassays. Toxicol Appl Pharmacol.1998 Mar;149(1):55-63.
[2] Morsy MA,Fouad AA. Mechanisms of gastroprotective effect of eugenol in indomethacin-induced ulcer in rats. Phytother Res.2008 Oct;22(10):1361-6.
[3] Gupta S,Das G. Clinical and radiographic evaluation of zinc oxide eugenol and metapex in root canal treatment of primary teeth. J Indian Soc Pedod Prev Dent.2011 Jul-Sep;29(3):222-8.
关键字： 97-53-0;C10H12O2;Eugenol;
上海一研生物科技有限公司Shanghai yiyan bio-technology Co. Ltd.主要从事免疫学、分子生物学和常规生化试剂等为一体的科研产品销售企业，公司自成立以来，秉承""全心全意服务于科研工作者""的企业理念，立足生物科技领域，运用生物技术和科研试剂，发展现代生物科技，为各类大中小医院及其它医疗机构、高等院校、科研院所、企事业单位提供优质的产品，服务生物科技领域的科学研究人员。
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