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Description
Glofitamab is a T-cell-engaging bispecific antibody possessing a novel 2:1 structure with bivalency for CD20 on B cells and monovalency for CD3 on T cells. Glofitamab is an investigational, T-cell bispecific antibody with a distinctive design that features 2 Fab arms for binding CD20 on B cells, along with 1 Fab arm for binding CD3 on T cells. The CD3 binding arm is fused directly to one of the CD20-binding arms in a head-to-tail fashion via a short flexible linker.
Catalog No.
DHC90714
Host species
Humanized
Species reactivity
Human
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Concentration
1 mg/ml
Purity
>95%
Clonality
Monoclonal
Isotype
IgG1-kappa-lambda
Applications
Research Grade Biosimilar
Target
B-lymphocyte surface antigen B1, Membrane-spanning 4-domains subfamily A member 1, MS4A1, Leukocyte surface antigen Leu-16, B-lymphocyte antigen CD20, Bp35, CD20, T3E, T-cell surface antigen T3/Leu-4 epsilon chain, CD3e, T-cell surface glycoprotein CD3 epsilon chain
Purification
Protein A or G purified from cell culture supernatant.
Endotoxin level
Please contact with the lab for this information.
Expression system
XtenCHO
Accession
P11836 & P07766
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.Store at +4°C short term (1-2 weeks).Store at -20 °C 12 months. Store at -80°C long term.
Alternative Names
Bispecific, CD20-TCB (2:1), RG-6026, CAS: 2229047-91-8
Note
For research use only. Not suitable for clinical or therapeutic use.
关键字： Glofitamab;格菲妥单抗;2229047-91-8;Bp35, CD20;MS4A1;
武汉佰乐博生物（Biolab Reagents）始创于 2021 年，核心创始团队由五位毕业于武汉大学、华中科技大学、华中农业大学等知名高校的生命科学领域顶尖研究者组成。团队成员均深耕行业二十载，积淀了深厚的产品开发实力与成熟的技术应用经验，为企业发展筑牢核心技术根基。
佰乐博生物是国家高新技术企业、国家科技型中小企业，技术实力获权威认可；同时通过 ISO9001 质量管理体系、ISO13485 医疗器械质量管理体系双认证，以标准化、规范化的品控体系，筑牢产品品质基石。公司依托全球领先的技术平台，专注于高品质生物试剂的全球化开发与整合，与法国 AntibodySystem 品牌达成深度战略合作，系其在亚洲的独家授权合作伙伴以及生工生物KleanAB品牌的代理商。目前已构建起近 60000 种生命科学试剂的丰富产品矩阵，核心产品涵盖蛋白、抗体、试剂盒三大品类，重点覆盖肿瘤、神经系统等疾病研究热门领域，可全维度满足各类科研实验的多元需求。
自成立以来，佰乐博生物始终秉持初心，致力于为广大生命科学科研工作者、生物医药工业客户提供专业、全面、可靠的试剂产品与技术支持，以优质科研工具赋能科研探索，助力生命科学研究领域实现创新发展与深度突破。