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Description
The FDA has granted an orphan drug designation to sotigalimab (APX005M) as a potential therapeutic option for patients with soft tissue sarcoma, according to announcement from Apexigen Inc., the drug developer. A novel, humanized monoclonal antibody, sotigalimab was designed stimulate antitumor immune response and to target CD40, which is a key co-stimulatory receptor that serves to activate innate and adaptive immune systems. When sotigalimab binds to CD40 on antigen-presenting cells, it induces a multifaceted immune response that brings several components of the immune system together to attack the cancer.
Catalog No.
DHD68911
Host species
Humanized
Species reactivity
Human
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Concentration
2.54 mg/ml
Purity
>95%
Clonality
Monoclonal
Isotype
IgG1-Kappa
Applications
Research Grade Biosimilar
Target
Tumor necrosis factor receptor superfamily member 5, B-cell surface antigen CD40, Bp50, CD40L receptor, TNFRSF5, CDw40, CD40
Purification
Protein A or G purified from cell culture supernatant.
Endotoxin level
Please contact with the lab for this information.
Expression system
XtenCHO
Accession
P25942
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.Store at +4°C short term (1-2 weeks).Store at -20 °C 12 months. Store at -80°C long term.
Alternative Names
APX005M, APX-005, APX-005-M, APX-005M, CAS: 2305607-45-6
Note
For research use only. Not suitable for clinical or therapeutic use.
关键字： Sotigalimab;2305607-45-6;Bp50;CDw40;
武汉佰乐博生物（Biolab Reagents）始创于 2021 年，核心创始团队由五位毕业于武汉大学、华中科技大学、华中农业大学等高校的生命科学领域资深研究者组成，团队深耕行业二十载，积淀了扎实的产品开发实力与技术应用经验，筑牢企业核心技术根基。
公司是国家高新技术企业、国家科技型中小企业，国家创新型中小企业，技术实力获权威认可，还通过 ISO9001、ISO13485 双质量管理体系认证，以标准化品控筑牢产品品质。依托全球领先技术平台，公司专注高品质生物试剂的全球化开发与整合，是法国 AntibodySystem 亚洲独家授权合作伙伴以及生工生物KleanAB品牌的合作伙伴，现构建起近 60000 种试剂的产品矩阵，核心涵盖蛋白、抗体、试剂盒，重点覆盖肿瘤、神经系统，病原菌感染等疾病研究领域，满足多元科研需求。
自成立以来，佰乐博生物始终为科研工作者、生物医药工业客户提供专业的产品与技术支持，以优质科研工具赋能科研，助力生命科学研究创新发展、深度突破。