Rabbit Anti-ALK Polyclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:ALK
IR:Immunogen Range:19-120/1620
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:238
Swiss Prot:Q9UM73
Source:KLH conjugated synthetic peptide derived from human ALK:19-120/1620
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), LK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X).[provided by RefSeq, Jan 2011].
Size:50ul
Concentration:1mg/ml
Applications:WB(1:500-2000)
ELISA(1:5000-10000)
Cross Reactive Species:Human
Mouse
Dog
Cow
Rabbit
仅供科研使用。不能用于人和动物治疗等其它临床诊断用！
关键字： ALK;ALK tyrosine kinase ; ALK/EML4 fusion gen;CD246;CD246 antigen;EC 2.7.10.1;NBLST3;TFG/ALK;
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