石衫碱甲

Product Structure

Product Name

(5R,9R,11E)- 5- amino-11-ethylidene-5,6,9,10-tetrahydro-7- methyl-5,9-Methanocycloocta[b]pyridin-2(1H)-one; (5R,9R,11E)-5-氨基-11-亚乙基-5,6,9,10-四氢-7-甲基-5,9- 亚甲基环辛四烯并(b)吡啶-2(1H)酮

(-)-Huperzine A; or (-)-Selagine

CAS No.

102518-79-6

Molecular Formula

C15H18N2O

M.W.

242.32

Manufacture Date

April 25, 2014

Batch No.

HDWK-HupA-140425-01

Report Date & No.

20140716-1

Quantity

580 gram

Standard

In-house

Test Items

Method

Specification

Results

Appearance

Visual

White to Off-white powder

White Powder

Passed

Identification

1H-NMR

Conform to Structure

Confirmed

Passed

13C-NMR

Conform to Structure

Confirmed

Passed

IR

Atlas of Infrared Spectra of Drugs (2010), Spec 936

Matched and Confirmed

Passed

UV

N.A.

For Information Only

Passed

LCMS

[M+1]+ = 243.4

[M +1]+ = 243.4

Passed

m.p.

217~219°C

217.5~219.0°C (DSC)

Passed

[α]D25

-150.4°(CHCl3)

-150.2°(c=0.51 in CHCl3)

Passed

Purity

HPLC

≥99.0%

>99.5% (100%, at 310nm)

Passed

Total Impurities

≤0.3%

<0.2%

Passed

Single Impurity

<0.1%

<0.08%

Passed

ee%

≥99.5%

100%

Passed

Water Contents

KF

<0.5%

0.26%

Passed

Loss on Drying

5h at 80°C in vacuo

≤4.0%

0.32%

Passed

Residual Solvents

GC

MeOH ≤ 200 ppm EtOH ≤ 1000 ppm CHCl3 ≤ 500 ppm

MeOH = 35 ppm EtOH = 265 ppm CHCl3 = 60 ppm

Passed

Residue Ignition

Muffle Furnase

N.A.

0.22% (Sulphated ash)

N.A.

Heavy Metal

Colorimetry

As < 1 ppm Pb < 10 ppm

Not Found Not Found

Passed

Conclusion

Conforms to the in-house standard