BC-1382 是一种有效的泛素 E3 连接酶 HECTD2 抑制剂,可特异性破坏 HECTD2/PIAS1 相互作用 (IC50≈ 5 nM)。具有抗炎活性。BC-1382 (10 mg/kg; intraperitoneal injection) significantly decreases lavage protein concentrations, lavage cell counts, and cell infiltrates in both PA103-stimulated and LPS-stimulated mice. BC-1382 significantly decreases lavage cytokine levels in both models
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