别名
EMD87580,N-[2-methyl-4,5-bis(methylsulfonyl)-benzoyl]-guanidine
应用
EMD-87580 has been used as a selective and potent sodium-hydrogen antiporter 1 (NHE-1) inhibitor in cardiac ventricular myocytes to test its effect on the hypertrophic response.
生化/生理作用
EMD-87580 is a selective inhibitor of the Na+/H+ exchanger subtype 1 (NHE-1), also known as the Na+/H+ antiporter. EMD-87580 has shown cardioprotective effects, and has been investigated as a possible treatment for Duchenne′s muscular dystrophy.
Sigma-Aldrich西格玛奥德里奇(上海)贸易有限公司
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