EMD-87580
| 中文名称 | EMD-87580 |
|---|---|
| 中文同义词 | 化合物RIMEPORIDE;N-氨基甲酰-2-甲基-4,5-双(甲磺酰)苯甲酰胺;N-(氨基氨基甲基)-2-甲基-4,5-双(甲基磺酰基)苯甲酰胺;化合物RIMEPORIDE,10 MM DMSO 溶液;Rimeporide 试剂;Rimeporide 试剂 |
| 英文名称 | Rimeporide |
| 英文同义词 | Rimeporide;N-carbamimidoyl-2-methyl-4,5-bis(methylsulfonyl)benzamide;N-(diaminomethylidene)-2-methyl-4,5-bis(methylsulfonyl)benzamide;EMD-87580;Benzamide, N-(aminoiminomethyl)-2-methyl-4,5-bis(methylsulfonyl)-;EMD-87580 >=98% (HPLC);Inhibitor,EMD87580,Sodium-hydrogen Exchanger,Sodium/hydrogen Exchanger,Rimeporide,inhibit,EMD 87580,Na+/H+ Exchanger (NHE);Rimeporide (EMD-87580) |
| CAS号 | 187870-78-6 |
| 分子式 | C11H15N3O5S2 |
| 分子量 | 333.38 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 187870-78-6.mol |
| 结构式 |  |
EMD-87580 性质
| 密度 | 1.55±0.1 g/cm3(Predicted) |
|---|---|
| 储存条件 | -20°C |
| 溶解度 | 二甲基亚砜：20 mg/mL（59.99 mM） |
| 形态 | 粉末 |
| 酸度系数(pKa) | 10.50±0.46(Predicted) |
| 颜色 | 白色至米色 |
| InChI | 1S/C11H15N3O5S2/c1-6-4-8(20(2,16)17)9(21(3,18)19)5-7(6)10(15)14-11(12)13/h4-5H,1-3H3,(H4,12,13,14,15) |
| InChIKey | GROMEQPXDKRRIE-UHFFFAOYSA-N |
| SMILES | NC(NC(C1=CC(S(=O)(C)=O)=C(S(=O)(C)=O)C=C1C)=O)=N |
Rimeporide (EMD-87580) 是一种有效的选择性 Na+/H+ 交换泵 (NHE-1) 抑制剂。
NHE1
Blocking NHE-1 activity has been shown to decrease intracellular Na + and Ca 2+ overload and pH and Rimeporide (EMD-87580) represents a new therapeutic option for duchenne muscular dystrophy (DMD). Rimeporide (EMD-87580) is expected to act as a muscle-sparing agent and its mode of action means that it is mutation independent.
安全信息
| WGK Germany | WGK 3 |
|---|---|
| 存储类别 | 11 - 可燃固体 |
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026/07/06 | S0312 | EMD-87580 Rimeporide | 187870-78-6 | 5mg | 5298.93元 |
| 2026/07/06 | S0312 | EMD-87580 Rimeporide | 187870-78-6 | 25mg | 15962.3元 |