中文名：Eliglustat
英文名：Eliglustat
纯度：Moligand™，≥98%
货号：E413855
Cas号：491833-29-5
存储温度：-20°C储存
运输条件：超低温运输
产品介绍：
Information
Eliglustat Eliglustat (GENZ-112638) inhibits glucosylceramide synthase(GCS) (IC50=20 nM in intact MDCK cells), thus reducing the load of glucosylceramide influx into the lysosome.
Targets
glucosylceramide synthase (In intact MDCK cells) 20 nM
In vitro
Eliglustat tartrate is designed and developed to inhibit glucosylceramide synthase, the enzyme that catalyzes the formation of glucosylceramide from UDP-glucose and ceramide.The inhibition of glucosylceramide synthase by eliglustat tartrate is highly specific. Eliglustat tartrate displays limited or no activity against a variety of glycosidases. Additionally, no inhibition of sucrase or maltase is observed at drug concentrations up to 10 μM.
In vivo
Preclinical studies in normal mice, rats and dogs with i.v. and oral administration demonstrates significant dose-related decreases in spleen, kidney and liver glucosylceramide content, consistent with prior observations with the palmitoyl homologue.In rodents, Genz-112638 is rapidly metabolized with a half-life of 15–45 minutes.
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关键字： 依那普利;EN300-259910 ; Genz 99067 ; s7852
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