aladdin 阿拉丁 V413898 VPS34-IN1 1383716-33-3 98%

中文名：VPS34-IN1

英文名：VPS34-IN1

纯度：Moligand™，≥98%

货号：V413898

Cas号：1383716-33-3

存储温度：-20°C储存

运输条件：超低温运输

产品介绍：

Information

VPS34-IN1 Vps34-IN1 is a potent and highly selective Vps34 inhibitor with IC50 of 25 nM invitro,which does not significantly inhibit the isoforms of class I as well as class II PI3Ks. Vps34-IN1 modulates autophagy .

Targets

Vps34 (Cell-free assay) 25 nM

In vitro

Administration of VPS34-IN1 to cells induces a rapid dose-dependent dispersal of a specific PtdIns(3)P-binding probe from endosome membranes, within 1min, without affecting the ability of class I PI3K to regulate Akt. It can also induce a rapid ~50-60% loss of SGK3 phosphorylation within 1min. VPS34-IN1 has no inhibition to the SGK2 isoform that does not possess a PtdIns(3)P-binding PX domain.

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