aladdin 阿拉丁 P414478 PF-00835231 870153-29-0 ≥98%

中文名：PF-00835231

英文名：PF-00835231

纯度：Moligand™，≥98%

货号：P414478

Cas号：870153-29-0

存储温度：避光,-20°C储存

运输条件：超低温运输

产品介绍：

Information

PF-00835231 PF-00835231 is a 3CL pro (M pro ) inhibitor that may targets SARS-CoV-2 protease 3CL pro as a potential new treatment for COVID-19.

Targets

3CL^pro

In vitro

A time-of-drug-addition approach delineates the timing of early SARS-CoV-2 life cycle steps in A549^+ACE2 cells and validates PF-00835231\'s early time of action. In a model of the human polarized airway epithelium, PF-00835231 potently inhibits SARS-CoV-2 at low micromolar concentrations. PF-00835231 exhibits the potential as an effective SARS-CoV-2 antiviral.

Cell Research(from reference)

Cell lines：A549 cells, human airway epithelial cultures (HAEC) 

Concentrations：1 nM-10 μM 

Incubation Time：0-4 h 

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