中文名:U73122,标准磷脂酶C(PLC)抑制剂
英文名:U73122
纯度:Moligand™,≥97%
货号:U302223
Cas号:112648-68-7
存储温度:-20°C储存
运输条件:超低温运输
产品介绍:
Application:
It is used as a phospholipase C, phospholipase A2, and 5-LO inhibitor. It is also determined that in SK-N-SH neuroblastoma cells, U-73122 inhibits agonist-induced down-regulation of muscarinic receptors. In addition, it is a useful tool to investigate receptor-mediated PI turnover in signal transduction. U-73122 is a potent inhibitor of human neutrophil adhesion to biological surfaces (IC50 = 50 nM) as well as adhesion-dependent granule exocytosis and oxidative burst. U-73343 (sc-201422) is useful as a negative control for investigations of U-73122 phospholipase C antagonism and its cellular consequences.
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