中文名：GS967
英文名：GS967
纯度：Moligand™，≥99%
货号：G413260
Cas号：1262618-39-2
存储温度：-20°C储存
运输条件：超低温运输
产品介绍：
Information
GS967 GS967 (GS458967) is a potent and selective inhibitor of late I Na with anti-arrhythmic actions.
Targets
late INa 0.13 μM
In vitro
GS967 (3 μM) has no significant effect on L- or T-type calcium channel currents or Na+-Ca2+ exchanger current (INCX), and 1 μM GS967 has minimal or no effect on the ATP-inhibited K+ current or on human cardiac ion channels expressed in human embryonic kidney 293 or Chinese hamster ovary cells. GS967 is a novel sodium channel modulatorspecifically developed to inhibit persistent sodium current, with a 42-fold preference for persistent as opposed to peakcurrent inhibition.
In vivo
GS967 protects against seizures and prematurelethality in vivo. Chronic GS967 does not cause overt behavioraltoxicity or sedation in wild-type mice at theeffective anticonvulsant dose. GS967 suppresses arrhythmogenicity evoked by ischemia, hypokalemia, and catecholamines in canine and porcine models.
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关键字： GS4589671,?2,?4-?Triazolo[4,?3-?a]?pyridine,6-?[4-?(trifluoromethoxy)?phenyl]?-?3-?(trifluoromethyl)?-
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