aladdin 阿拉丁 P409126 PLX5622 1303420-67-8 10mM in DMSO

中文名：PLX5622

英文名：PLX5622

英文别名：3-​Pyridinemethanamine, 5-​fluoro-​N-​[6-​fluoro-​5-​[(5-​methyl-​1H-​pyrrolo[2,​3-​b]​pyridin-​3-​yl)​methyl]​-​2-​pyridinyl]​-​2-​methoxy-

纯度：10mM in DMSO

货号：P409126

包装：1ml

Cas号：1303420-67-8

存储温度：-80℃储存

产品介绍：

Information

PLX5622 PLX5622 is a highly selective CSF-1R inhibitor (IC50 < 10 nmol/L), showing > 20-fold selectivity over KIT and FLT3.
In vitro

In vivo

In vivo PLX5622 demonstrates desirable PK properties in mice, rats, dogs, and monkeys, with a brain penetrance of ~20%. PLX5622 has low systemic clearance, moderate volume of distribution, and favorable oral bioavailability (F > 30%) in all four species. PLX5622 is a useful compound for investigating microglial dynamics. It allows for the sustained and specific elimination of microglia, preceding and during pathology development of Alzheimer’s disease (AD). Long-term PLX5622-mediated microglial depletion is highly robust, sustainable, and specific to the microglial compartment.
Cell Data

cell lines：Ba/F3 cells expressing JAK2V617F (Ba/F3-EpoR-V617F) and MPLW515L (Ba/F3-W515L) mutants.

Concentrations：

Incubation Time：

Powder Purity:≥98%

查看阿拉丁官网此产品相关对应页面：https://www.aladdin-e.com/zh_cn/P409126.html