中文名：ML364
英文名：ML364
纯度：≥99%
货号：M413614
Cas号：1991986-30-1
存储温度：-20°C储存
运输条件：超低温运输
产品介绍：
Information
ML364 is a small molecule inhibitor of thedeubiquitinase USP2with an IC50 of 1.1 μM in a biochemical assay using an internally quenched fluorescent di-ubiquitin substrate.
Targets
USP8 (Cell-free assay); USP2 (Cell-free assay) 0.95 μM; 1.1 μM
In vitro
ML364 induces an increase in cellular cyclin D1 degradation and causes cell cycle arrest in Mino and HCT116 cancer cell lines. ML364 is antiproliferative in cancer cell lines. ML364 also causes a decrease in homologous recombination-mediated DNA repair. It is inactive against caspase 6, caspase 7, MMP1, MMP9, and USP15, but does inhibit USP8 with an IC50 of 0.95 μM. In a panel of 102 kinases that included regulators of the cell cycle there is no binding observed to any of the enzymes tested using 10 μM ML364.
Cell Research(from reference)
Cell lines：LnCAP cells and MCF7 cells
Concentrations：0-20 μM
Incubation Time：24 h
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关键字： 2-[[[(4-甲基苯基)磺酰基]氨基] -N-(4-苯基-2-噻唑基)-4-(三氟甲基)-苯甲酰胺, 2-(4-甲基苯基磺酰胺基)-N-(4-苯基噻唑-2-基)-4-(三氟甲基)苯甲酰胺;ML364
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