aladdin 阿拉丁 C413721 CNX-2006 1375465-09-0 98%

中文名：CNX-2006

英文名：CNX-2006

纯度：≥98%

货号：C413721

Cas号：1375465-09-0

存储温度：-20°C储存

运输条件：超低温运输

产品介绍：

Information

CNX-2006 is a novel irreversible mutant-selectiveEGFRinhibitor withIC50of < 20 nM, with very weak inhibition at wild-type EGFR.

Targets

mutant EGFR <20 nM

In vitro

CNX-2006 is a novel irreversible EGFR tyrosine kinase inhibitor, specifically inhibits activating mutations of EGFR as well as the T790M mutation while having very weak inhibition at wild-type EGFR. In in vitro modeling of acquired resistance, continuous CNX-2006 treatment on drug-sensitive EGFR mutant cells leads to resistance more slowly than erlotinib. Dose escalation with CNX-2006 leads to differential effects in different lines, but does not select for T790M-mediated resistance. CNX-2006 resistent cells shows increased expression of EMT markers and MMP9.

In vivo

CNX-2006 is effective in H1975 (EGFR L858R/T790M) xenograft model.

Cell Research(from reference)

Cell lines：HEK293 

Concentrations：~1000 nM 

Incubation Time：6 h 

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