Human DLL1 / Delta1 Protein, His Tag, premium grade
分子别名(Synonym)
DLL1,Delta1,H-Delta-1
表达区间及表达系统(Source)
Human DLL1 Protein, His Tag, premium grade (DL1-H52H8) is expressed from human 293 cells (HEK293). It contains AA Gln 18 - Gly 540 (Accession # NP_005609).
Predicted N-terminus: Gln 18
该产品是在我们严格的质量控制体系下生产的,该体系包含一套全面的测试,包括无菌和内毒素测试。在早期临床前阶段,产品性能经过仔细验证和测试,以确保其与细胞培养用途或任何其他应用的兼容性。当准备过渡到后期临床阶段时,我们还提供定制的GMP蛋白质服务,以满足您的需求。我们将与您合作,根据您的要求定制和开发GMP级产品,该产品也符合细胞疗法细胞制造中使用的原材料和辅助材料的要求。
蛋白结构(Molecular Characterization)

This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 58.4 kDa. The protein migrates as 60-65 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
内毒素(Endotoxin)
Less than 0.01 EU per μg by the LAL method.
无菌(Sterility)
Negative
支原体(Mycoplasma)
Negative.
纯度(Purity)
>95% as determined by SDS-PAGE.
>90% as determined by SEC-MALS.
制剂(Formulation)
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
重构方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存储(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.


背景(Background)
DLL1也称为Delta1或H-Delta-1,它包含一个DSL结构域和八个EGF样结构域。DLL1被MIB(MIB1或MIB2)泛素化,导致其内吞作用和随后的降解。在表达方面,DLL1在心脏和胰腺中表达,在脑和肌肉中表达较低,在胎盘、肺、肝和肾中几乎不表达。此外,DLL1充当Notch受体的配体。此外,DLL1可以阻断祖细胞分化为B细胞谱系,同时促进具有T-C/NK细胞前体特征的细胞群的出现。
关键字: DLL1;DLL1蛋白;DLL1重组蛋白;ACRO;百普赛斯;
百普赛斯集团ACROBiosystems Group(股票代码:301080)是成立于2010年的跨国生物科技公司,是为全球生物医药、健康产业领域提供关键生物试剂产品及解决方案的行业平台型基石企业。2021年在创业板上市。百普赛斯集团业务遍布全球,横跨亚洲、北美洲、欧洲,在中国、美国、瑞士等12个城市设有办公室、研发中心及生产基地。目前累计服务客户超6000家,与全球Top 20医药企业均建立了长期、稳定的合作伙伴关系。集团旗下拥有品牌ACROBiosystems百普赛斯、bioSeedin柏思荟、Condense Capital垦拓资本和ACRODiagnostics百斯医学等。