Human Apolipoprotein E / APOE3 Protein, His Tag
分子别名(Synonym)
Apolipoprotein E,APOE,Apo-E
表达区间及表达系统(Source)
Human APOE3, His Tag (APE-H5246) is expressed from human 293 cells (HEK293). It contains AA Lys 19 - His 317 (Accession # P02649-1).
Predicted N-terminus: Lys 19
蛋白结构(Molecular Characterization)

This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 36.1 kDa. The protein migrates as 35-40 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
内毒素(Endotoxin)
Less than 1.0 EU per μg by the LAL method.
无菌(Sterility)
Negative
纯度(Purity)
>90% as determined by SDS-PAGE.
制剂(Formulation)
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
重构方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存储(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.



背景(Background)
APOE是一种载脂蛋白,一种与脂质颗粒相关的蛋白质,主要通过血浆和间质液在脂蛋白介导的器官间脂质运输中发挥作用。载脂蛋白E是血浆脂蛋白的核心成分,参与其产生、转化和清除。载脂蛋白是两亲性分子,与脂蛋白颗粒核心的脂质和血浆的水环境相互作用。因此,APOE与乳糜微粒、乳糜微粒残留、极低密度脂蛋白(VLDL)和中密度脂蛋白。它还与多种细胞受体结合,包括LDL受体/LDLR、LDL受体相关蛋白LRP1、LRP2和LRP8以及极低密度脂蛋白受体/VDLR,这些受体介导含APOE的脂蛋白颗粒的细胞摄取。
关键字: Apolipoprotein E;APOE蛋白;APOE重组蛋白;ACRO;百普赛斯;
百普赛斯集团ACROBiosystems Group(股票代码:301080)是成立于2010年的跨国生物科技公司,是为全球生物医药、健康产业领域提供关键生物试剂产品及解决方案的行业平台型基石企业。2021年在创业板上市。百普赛斯集团业务遍布全球,横跨亚洲、北美洲、欧洲,在中国、美国、瑞士等12个城市设有办公室、研发中心及生产基地。目前累计服务客户超6000家,与全球Top 20医药企业均建立了长期、稳定的合作伙伴关系。集团旗下拥有品牌ACROBiosystems百普赛斯、bioSeedin柏思荟、Condense Capital垦拓资本和ACRODiagnostics百斯医学等。