Human CCR4 Full Length Protein, Flag,His Tag (Detergent)
分子别名（Synonym）
CKR4, K5-5,CD194,CMKBR4,ChemR13,CC-CKR-4,HGCN:14099
表达区间及表达系统（Source）
Human CCR4 Full Length Protein, Flag,His Tag (CC4-H52D3) is expressed from human 293 cells (HEK293). It contains AA Asn 2 - Leu 360 (Accession # P51679-1).
Predicted N-terminus: Asp
蛋白结构（Molecular Characterization）
This protein carries flag tag at the N-terminus and polyhistidine tag at the C-terminus.
The protein has a calculated MW of 60.3 kDa.
内毒素（Endotoxin）
Less than 1.0 EU per μg by the LAL method.
纯度（Purity）
>80% as determined by SDS-PAGE.
制剂（Formulation）
This product is not suitable for cell based experiments due to cytotoxicity of DDM.
DDM and CHS are INDISPENSABLE to keep membrane protein soluble and active, under no circumastance should you remove DDM and CHS.
DDM/CHS buffer (DC-11) is sold separately and not included in protein, and please contact us if you need the buffer.
If glycerol is not compatible to your application, remove glycerol just before immediate experiment, and NEVER store glycerol-free protein solution.
Supplied as 0.2 μm filtered solution in 50 mM HEPES, 150 mM NaCl, DDM, CHS,pH7.5 with glycerol as protectant.
Contact us for customized product form or formulation.
运输（Shipping）
This product is supplied and shipped with dry ice, please inquire the shipping cost.
存储（Storage）
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
The product MUST be stored at -70°C or lower upon receipt;
-70°C for 3 months under sterile conditions.
背景（Background）
C-C趋化因子受体4型是以下CC趋化因子的受体：CCL2、CCL4、CCL5、CCL17、CCL22，属于G蛋白偶联受体家族。趋化因子是一组小多肽，结构上相关的分子，调节各种类型白细胞的细胞运输。趋化因子在免疫系统的发育、稳态和功能中也起着重要作用，它们对中枢神经系统细胞以及参与血管生成或血管停滞的内皮细胞都有影响。CCR4通常在皮肤T细胞淋巴瘤（CTCL）的白血病细胞上表达。Mogamulizumab是一种针对CCR4的人源化单克隆抗体，是CTCL的研究药物。
关键字： CCR4;CCR4蛋白;CCR4重组蛋白;ACRO;百普赛斯;
百普赛斯集团ACROBiosystems Group（股票代码：301080）是成立于2010年的跨国生物科技公司，是为全球生物医药、健康产业领域提供关键生物试剂产品及解决方案的行业平台型基石企业。2021年在创业板上市。百普赛斯集团业务遍布全球，横跨亚洲、北美洲、欧洲，在中国、美国、瑞士等12个城市设有办公室、研发中心及生产基地。目前累计服务客户超6000家，与全球Top 20医药企业均建立了长期、稳定的合作伙伴关系。集团旗下拥有品牌ACROBiosystems百普赛斯、bioSeedin柏思荟、Condense Capital垦拓资本和ACRODiagnostics百斯医学等。