Human AIMP1 / EMAP2 / SCYE1 Protein, His Tag
分子别名(Synonym)
AIMP1,EMAP2,SCYE1
表达区间及表达系统(Source)
Human AIMP1, His Tag (EM2-H5142) is expressed from E. coli cells. It contains AA Ala 2 - Lys 312 (Accession # Q12904-1).
Predicted N-terminus: Met
蛋白结构(Molecular Characterization)

This protein carries a polyhistidine tag at the N-terminus.
The protein has a calculated MW of 35.2 kDa. The protein migrates as 36 kDa under reducing (R) condition (SDS-PAGE).
内毒素(Endotoxin)
Less than 1.0 EU per μg by the LAL method.
纯度(Purity)
>95% as determined by SDS-PAGE.
制剂(Formulation)
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.
Contact us for customized product form or formulation.
重构方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存储(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.

背景(Background)
氨基酰基tRNA合酶复合物相互作用多功能蛋白1(AIMP1)也被称为多合相复合物辅助成分p43和内皮单核细胞激活多肽II(EMAP-II)。AIMP1是一种细胞因子,可由凋亡诱导,也可从树突状细胞等专业抗原呈递细胞中释放。AIMP1的释放使肿瘤相关血管系统对肿瘤坏死因子敏感。此外,AIMP1结合tRNA并刺激细胞质精氨酸-tRNA合酶的催化活性。这种蛋白质具有炎性细胞因子活性。此外,AIMP1通过与SMURF2结合并抑制其SMAD7介导的降解来稳定SMURF2,从而负向调节TGF-β信号传导。
关键字: AIMP1;EMAP2蛋白;SCYE1重组蛋白;ACRO;百普赛斯;
百普赛斯集团ACROBiosystems Group(股票代码:301080)是成立于2010年的跨国生物科技公司,是为全球生物医药、健康产业领域提供关键生物试剂产品及解决方案的行业平台型基石企业。2021年在创业板上市。百普赛斯集团业务遍布全球,横跨亚洲、北美洲、欧洲,在中国、美国、瑞士等12个城市设有办公室、研发中心及生产基地。目前累计服务客户超6000家,与全球Top 20医药企业均建立了长期、稳定的合作伙伴关系。集团旗下拥有品牌ACROBiosystems百普赛斯、bioSeedin柏思荟、Condense Capital垦拓资本和ACRODiagnostics百斯医学等。