Rabbit Polyclonal SLC2A3 Antibody

+ +

•  

   

     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Human colorectal cancer tissue lysate, Primary antibody: P03994(SLC2A3 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 minutes    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P03994(SLC2A3 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

The SLC2A3 antibody is a research tool designed to detect the solute carrier family 2 member 3 (SLC2A3), also known as glucose transporter 3 (GLUT3). Encoded by the SLC2A3 gene, GLUT3 is a transmembrane protein responsible for facilitating glucose uptake across cell membranes. Predominantly expressed in neurons, GLUT3 ensures high-affinity glucose transport to meet the brain’s substantial energy demands. It also plays roles in other tissues, including the placenta, sperm, and certain cancer cells, where glucose metabolism is critical for function or proliferation.

SLC2A3 antibodies are widely used in biomedical research to study GLUT3 expression patterns, localization, and regulation under physiological or pathological conditions. These antibodies enable techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to investigate GLUT3’s involvement in diseases such as Alzheimer’s, diabetes, and cancers, where altered glucose metabolism is a hallmark. For instance, upregulated GLUT3 in tumors is associated with aggressive growth and poor prognosis, making it a potential therapeutic target.

Antibody specificity is validated using knockout controls or siRNA-mediated gene silencing to confirm binding to the 55 kDa GLUT3 protein. Researchers select SLC2A3 antibodies based on host species (e.g., rabbit, mouse), clonality (monoclonal/polyclonal), and applications. Proper validation ensures reliable detection, critical for studies exploring metabolic dysregulation or developing diagnostic biomarkers. Overall, SLC2A3 antibodies are indispensable for dissecting glucose transport mechanisms and their implications in health and disease.