Rabbit Polyclonal SLC2A12 Antibody

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Human placenta tissue lysate, Primary antibody: P03998(SLC2A12 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 10 minutes    

  
  

The SLC2A12 antibody targets the solute carrier family 2 member 12 (SLC2A12), a protein encoded by the *SLC2A12* gene, also known as GLUT12. This transporter belongs to the facilitative glucose transporter (GLUT) family, which mediates cellular uptake of glucose and other hexoses. GLUT12 is implicated in insulin-sensitive glucose transport, particularly in tissues like skeletal muscle, adipose tissue, and the placenta. It plays a potential role in metabolic disorders, including diabetes and cancer, due to its altered expression in pathological conditions.

SLC2A12 antibodies are typically developed using recombinant proteins or synthetic peptides corresponding to specific epitopes of the GLUT12 protein. These antibodies are essential tools for detecting and quantifying GLUT12 expression in research applications such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). They help elucidate the protein’s localization, expression patterns in normal versus diseased tissues, and its interaction with signaling pathways.

Studies using SLC2A12 antibodies have revealed its upregulation in certain cancers, suggesting a link between glucose metabolism dysregulation and tumor progression. However, challenges remain, such as ensuring antibody specificity due to structural similarities among GLUT family members. Validation via knockout controls or siRNA silencing is critical. Overall, SLC2A12 antibodies are vital for advancing research into metabolic diseases, cancer biology, and therapeutic targeting of glucose transport mechanisms.