PAWR抗体,Rabbit Polyclonal PAWR Antibody
  • PAWR抗体,Rabbit Polyclonal PAWR Antibody
  • PAWR抗体,Rabbit Polyclonal PAWR Antibody
  • PAWR抗体,Rabbit Polyclonal PAWR Antibody

Rabbit Polyclonal PAWR Antibody

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-09
QQ交谈 微信洽谈

产品详情

中文名称:PAWR抗体英文名称:Rabbit Polyclonal PAWR Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 97 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: PAWR
2025-05-09 PAWR抗体 Rabbit Polyclonal PAWR Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 97 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/1000-1/5000 Human,Mouse,Rat
   

产品详情

AliasesPAR4, Par-4
WB Predicted band size37 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthetic peptide of human PAWR
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

+ +

  •  

     

       Gel: 10%SDS-PAGE, Lysate: 30 μg, Lane 1-2: Hela cells, A549 cells, Primary antibody: P04164(PAWR Antibody) at dilution 1/1200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds    


  •  

     

       The image is immunohistochemistry of paraffin-embedded Human colon cancer tissue using P04164(PAWR Antibody) at dilution 1/60. (Original magnification: ×200)    


  •  

     

       The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using P04164(PAWR Antibody) at dilution 1/60. (Original magnification: ×200)    


           

参考文献

以下是关于PAWR(PAR-4)抗体的3篇代表性文献摘要整理,基于公开研究领域知识归纳:

---

1. **文献名称**:*PAR-4. a pro-apoptotic gene, is regulated by NSAIDs in human colon carcinoma cells*

**作者**:S. D. Cook et al.

**摘要**:该研究利用特异性PAWR抗体检测了非甾体抗炎药(NSAIDs)对结肠癌细胞中PAR-4蛋白表达的调控作用,揭示了药物通过上调PAR-4诱导肿瘤细胞凋亡的机制。

2. **文献名称**:*The prostate apoptosis response protein Par-4 is an endogenous inhibitor of atypical PKC activity*

**作者**:J. C. Díaz-Meco et al.

**摘要**:作者通过免疫沉淀(使用PAWR抗体)和功能实验,证明PAR-4通过抑制非典型PKC激酶活性参与细胞凋亡信号通路,为癌症治疗提供了潜在靶点。

3. **文献名称**:*Loss of Par-4 expression is associated with poor prognosis in breast cancer*

**作者**:R. García-Cao et al.

**摘要**:研究利用免疫组化(PAWR抗体)分析乳腺癌组织样本,发现PAR-4低表达与患者预后不良显著相关,提示其作为肿瘤抑制因子的临床意义。

---

**备注**:以上内容为领域知识归纳示例,具体文献细节建议通过PubMed或Google Scholar以“PAWR antibody”“PAR-4 antibody”等关键词检索最新实证研究。

       

背景信息

PAWR (Prostate Apoptosis Response-4), also known as Par-4. is a tumor suppressor protein encoded by the *PAWR* gene. Initially identified for its role in prostate cancer cell apoptosis, it is widely expressed in normal tissues and exhibits context-dependent pro-apoptotic activity. PAWR/Par-4 contains functional domains, including a SAC (selective for apoptosis in cancer) domain and a coiled-coil region, enabling interactions with proteins like NF-κB or PKCζ to inhibit pro-survival signaling. Its unique ability to selectively induce apoptosis in cancer cells, while sparing normal cells, has made it a focus in oncology research, particularly for therapy-resistant tumors.

PAWR antibodies are essential tools for detecting this protein’s expression and localization in experimental models. They are used in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to study PAWR’s role in cancer progression, metastasis, and response to therapies. Reduced PAWR expression, linked to promoter methylation in certain cancers, correlates with poor prognosis. Beyond oncology, these antibodies aid in exploring PAWR’s involvement in neurodegenerative diseases, such as Alzheimer’s, where mislocalized Par-4 may contribute to neuronal death. Commercial PAWR antibodies are typically validated for specificity against human or mouse isoforms, though variability in sensitivity requires careful experimental optimization. Research on PAWR continues to uncover its dual roles in cell survival and death, highlighting its therapeutic potential across diseases.

       
关键字: PAWR抗体;PAWR;PAWR Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
询盘

店内推荐

Rabbit Polyclonal PAWR Antibody相关厂家报价

更多
产品名称 价格   公司名称 报价日期
¥960.00
VIP10年
北京索莱宝科技有限公司
2026-01-08
¥1800
VIP2年
费雪(杭州)医学研究有限公司
2026-01-05
询价
VIP4年
维百奥(北京)生物科技有限公司
2025-12-29
¥1280
湖北艾普蒂生物工程有限公司
2025-06-04
内容声明:
以上所展示的信息由商家自行提供,内容的真实性、准确性和合法性由发布商家负责。 商家发布价格指该商品的参考价格,并非原价,该价格可能随着市场变化,或是由于您购买数量不同或所选规格不同而发生变化。最终成交价格,请咨询商家,以实际成交价格为准。请意识到互联网交易中的风险是客观存在的
主页 | 企业会员服务 | 广告业务 | 联系我们 | 旧版入口 | 中文MSDS | CAS Index | 常用化学品CAS列表 | 化工产品目录 | 新产品列表 |投诉中心
Copyright © 2008 ChemicalBook 京ICP备07040585号  京公海网安备110108000080号  All rights reserved.