SLC12A6抗体,Rabbit Polyclonal SLC12A6 Antibody
  • SLC12A6抗体,Rabbit Polyclonal SLC12A6 Antibody
  • SLC12A6抗体,Rabbit Polyclonal SLC12A6 Antibody
  • SLC12A6抗体,Rabbit Polyclonal SLC12A6 Antibody

Rabbit Polyclonal SLC12A6 Antibody

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-09
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产品详情

中文名称:SLC12A6抗体英文名称:Rabbit Polyclonal SLC12A6 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 108 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: SLC12A6
2025-05-09 SLC12A6抗体 Rabbit Polyclonal SLC12A6 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 108 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/50-1/200 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/2000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesHPRG; HRGP; THPH11
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthetic peptide of human HRG
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       The image is immunohistochemistry of paraffin-embedded Human colon cancer tissue using P11823(HRG Antibody) at dilution 1/50. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P11823(HRG Antibody) at dilution 1/50. (Original magnification: ×200)    


           

参考文献

以下是关于SLC12A6抗体的3篇文献示例(内容为虚构模拟,仅供参考):

1. **文献名称**:*Expression and localization of the K+-Cl− cotransporter SLC12A6 in the developing mouse brain*

**作者**:Howard, E. et al.

**摘要**:本研究通过免疫组化技术结合特异性SLC12A6抗体,揭示了该蛋白在小鼠胚胎及出生后脑组织中的动态表达模式,提示其在神经元迁移和突触形成中的潜在作用。

2. **文献名称**:*Functional characterization of SLC12A6 mutations in Andermann syndrome using custom-generated antibodies*

**作者**:Delpire, E. & Mount, D.B.

**摘要**:作者开发了针对SLC12A6的兔源多克隆抗体,并在患者来源的细胞模型中验证了致病突变导致的蛋白表达异常,为Andermann综合征的分子机制提供了实验证据。

3. **文献名称**:*SLC12A6-mediated ion transport in peripheral nerve myelination: Insights from antibody-based inhibition assays*

**作者**:Karadsheh, M. et al.

**摘要**:利用SLC12A6特异性抗体阻断其功能,研究发现该蛋白缺失会导致施万细胞离子稳态紊乱,进而影响周围神经髓鞘形成。

(注:以上文献为示例,实际引用请通过PubMed或SciHub等平台检索真实发表论文。)

       

背景信息

The SLC12A6 antibody is a tool used to detect the solute carrier family 12 member 6 (SLC12A6) protein, also known as potassium-chloride cotransporter 3 (KCC3). This transmembrane protein, encoded by the *SLC12A6* gene, plays a critical role in regulating intracellular chloride and potassium ion homeostasis, particularly in neurons and peripheral nerves. It facilitates electroneutral ion transport, contributing to cell volume regulation and neuronal excitability. Dysfunction of SLC12A6 is linked to neurological disorders, including Andermann syndrome (a rare autosomal recessive condition characterized by agenesis of the corpus callosum, peripheral neuropathy, and developmental delays) and other neuromuscular pathologies.

SLC12A6 antibodies are widely utilized in research to investigate the protein's expression, localization, and functional interactions. They are applied in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to study tissue-specific distribution, particularly in the nervous system. Studies using these antibodies have revealed SLC12A6's involvement in axonal maintenance, synaptic function, and osmoregulation. Additionally, the antibody aids in exploring disease mechanisms, such as how SLC12A6 mutations disrupt ion transport, leading to neurodegeneration. Its role in cancer cell migration and epilepsy has also been investigated, highlighting its broader physiological relevance. Validated antibodies are essential for distinguishing between SLC12A6 isoforms and assessing post-translational modifications, contributing to targeted therapeutic research.

       
关键字: SLC12A6抗体;SLC12A6;SLC12A6 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
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