TNIP3抗体,Rabbit Polyclonal TNIP3 Antibody
  • TNIP3抗体,Rabbit Polyclonal TNIP3 Antibody
  • TNIP3抗体,Rabbit Polyclonal TNIP3 Antibody
  • TNIP3抗体,Rabbit Polyclonal TNIP3 Antibody

Rabbit Polyclonal TNIP3 Antibody

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-09
QQ交谈 微信洽谈

产品详情

中文名称:TNIP3抗体英文名称:Rabbit Polyclonal TNIP3 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 134 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: TNIP3
2025-05-09 TNIP3抗体 Rabbit Polyclonal TNIP3 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 134 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC咨询技术 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/1000-1/2000 Human,Mouse,Rat
   

产品详情

AliasesLIND; ABIN-3
WB Predicted band size39 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenSynthetic peptide of human TNIP3
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

+ +

  •  

     

       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Mouse brain tissue, Primary antibody: P04250(TNIP3 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    


           

参考文献

以下是关于TNIP3抗体的虚构参考文献示例(仅供示例参考,非真实文献):

---

1. **文献名称**:*TNIP3 modulates NF-κB signaling through interaction with ubiquitin chains*

**作者**:Lee S, et al.

**摘要**:研究通过TNIP3抗体进行免疫共沉淀和Western blot,发现TNIP3通过与泛素链结合抑制NF-κB通路活性,影响炎症反应调控。

2. **文献名称**:*TNIP3 antibody-based profiling reveals its tumor-suppressive role in hepatocellular carcinoma*

**作者**:Zhang Y, et al.

**摘要**:利用TNIP3特异性抗体进行免疫组化分析,证明TNIP3在肝癌组织中低表达,并通过调控细胞凋亡抑制肿瘤生长。

3. **文献名称**:*TNIP3 regulates viral innate immunity via interaction with RIG-I*

**作者**:Kumar A, et al.

**摘要**:通过TNIP3抗体的免疫荧光染色,发现TNIP3与RIG-I蛋白互作,负向调控抗病毒天然免疫信号通路。

4. **文献名称**:*TNIP3 deficiency exacerbates autoimmune disorders in murine models*

**作者**:Müller R, et al.

**摘要**:采用TNIP3敲除小鼠及抗体检测,揭示TNIP3缺失导致B细胞过度活化,促进系统性红斑狼疮等自身免疫疾病发展。

---

**注意**:以上文献为示例性内容,实际研究中请通过学术数据库(如PubMed、Web of Science)检索真实文献。

       

背景信息

TNIP3 (TNFAIP3-interacting protein 3), also known as ABIN3. is a ubiquitin-binding protein that regulates inflammatory signaling pathways, particularly those mediated by NF-κB. It shares structural homology with other ABIN family members (TNIP1. TNIP2) and contains conserved domains, including a ubiquitin-binding domain (UBAN) and an NF-κB essential modulator (NEMO)-binding domain. TNIP3 interacts with TNFAIP3 (A20), a critical negative regulator of NF-κB, to modulate immune responses, apoptosis, and cell survival. Dysregulation of TNIP3 has been implicated in autoimmune diseases, cancers, and inflammatory disorders.

Antibodies targeting TNIP3 are essential tools for investigating its expression, localization, and molecular interactions. They enable researchers to study TNIP3's role in fine-tuning NF-κB activation, either by stabilizing A20's deubiquitinase activity or through competitive binding with other signaling components. Western blotting, immunohistochemistry, and co-immunoprecipitation are common applications. Studies using TNIP3 antibodies have revealed tissue-specific expression patterns and disease-associated alterations, such as reduced levels in lupus or aberrant expression in certain lymphomas. However, challenges remain in distinguishing TNIP3 from homologous proteins due to sequence conservation, necessitating rigorous antibody validation. These reagents continue to advance our understanding of TNIP3's dual roles as a tumor suppressor and context-dependent oncogenic collaborator.

       
关键字: TNIP3抗体;TNIP3;TNIP3 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
询盘

店内推荐

Rabbit Polyclonal TNIP3 Antibody相关厂家报价

产品名称 价格   公司名称 报价日期
¥960.00
VIP10年
北京索莱宝科技有限公司
2026-02-10
询价
上海华盈生物医药科技有限公司
2026-02-15
询价
VIP4年
维百奥(北京)生物科技有限公司
2025-12-29
内容声明:
以上所展示的信息由商家自行提供,内容的真实性、准确性和合法性由发布商家负责。 商家发布价格指该商品的参考价格,并非原价,该价格可能随着市场变化,或是由于您购买数量不同或所选规格不同而发生变化。最终成交价格,请咨询商家,以实际成交价格为准。请意识到互联网交易中的风险是客观存在的
主页 | 企业会员服务 | 广告业务 | 联系我们 | 旧版入口 | 中文MSDS | CAS Index | 常用化学品CAS列表 | 化工产品目录 | 新产品列表 |投诉中心
Copyright © 2008 ChemicalBook 京ICP备07040585号  京公海网安备110108000080号  All rights reserved.