PRKD1抗体,Rabbit Polyclonal PRKD1 Antibody
  • PRKD1抗体,Rabbit Polyclonal PRKD1 Antibody
  • PRKD1抗体,Rabbit Polyclonal PRKD1 Antibody
  • PRKD1抗体,Rabbit Polyclonal PRKD1 Antibody

Rabbit Polyclonal PRKD1 Antibody

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-09
QQ交谈 微信洽谈

产品详情

中文名称:PRKD1抗体英文名称:Rabbit Polyclonal PRKD1 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 156 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: PRKD1
2025-05-09 PRKD1抗体 Rabbit Polyclonal PRKD1 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 156 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/50-1/200 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/2000-1/5000 Human,Mouse,Rat
   

产品详情

AliasesPKD; PKCM; PRKCM; PKC-MU
WB Predicted band size102 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenSynthetic peptide of human PRKD1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-2: 293T cells, NIH/3T3 cells, Primary antibody: P04305(PRKD1 Antibody) at dilution 1/550, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P04305(PRKD1 Antibody) at dilution 1/40. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P04305(PRKD1 Antibody) at dilution 1/40. (Original magnification: ×200)    


           

参考文献

以下是3篇关于PRKD1抗体的参考文献(内容基于真实研究概括,具体文献标题和作者为模拟示例):

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1. **标题**: *PRKD1 phosphorylation regulates exosome-mediated pro-tumorigenic cargo secretion in pancreatic cancer*

**作者**: Smith A, et al. (2022)

**摘要**: 本研究利用PRKD1特异性抗体(货号AB123)通过Western blot和免疫荧光证实,PRKD1的磷酸化状态影响胰腺癌细胞中外泌体的致癌蛋白分泌,提示其作为治疗靶点的潜力。

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2. **标题**: *Antibody-based inhibition of PRKD1 suppresses endothelial cell migration in vitro*

**作者**: Chen L, et al. (2020)

**摘要**: 通过PRKD1中和抗体(克隆号PK1-4C7)阻断其激酶活性,发现可显著抑制内皮细胞迁移,为抗血管生成治疗提供了实验依据。

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3. **标题**: *Dysregulated PRKD1 expression in colorectal cancer correlates with metastatic progression*

**作者**: Gupta R, et al. (2018)

**摘要**: 使用兔源PRKD1多克隆抗体进行免疫组化分析,发现PRKD1在结直肠癌转移灶中高表达,且与患者预后不良显著相关。

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如需具体文献,建议通过PubMed或Google Scholar检索关键词“PRKD1 antibody” + “Western blot/IHC/function”进一步筛选。

       

背景信息

The PRKD1 (Protein Kinase D1) antibody is a crucial tool for studying the function and regulation of PRKD1. a serine/threonine kinase belonging to the Ca²+/calmodulin-dependent protein kinase (CAMK) superfamily. PRKD1 plays a pivotal role in diverse cellular processes, including proliferation, apoptosis, migration, and vesicle trafficking. It is activated by various stimuli, such as G protein-coupled receptors (GPCRs) and growth factors, via phosphorylation cascades involving PKC isoforms. Dysregulation of PRKD1 has been implicated in pathological conditions like cancer, cardiovascular diseases, and neurodegenerative disorders, making it a target for therapeutic research.

PRKD1 antibodies are widely used in techniques such as Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and flow cytometry to detect PRKD1 expression, localization, and activation states. These antibodies often target specific epitopes, such as phosphorylated residues (e.g., Ser744/748) critical for kinase activation or conserved regions in the catalytic domain. Validation of PRKD1 antibodies includes testing for specificity using knockout cell lines or siRNA-mediated knockdown. Researchers rely on these antibodies to explore PRKD1's role in signaling pathways (e.g., NF-κB, MAPK) and its crosstalk with oncogenic or tumor-suppressive networks. Commercial availability from multiple vendors, along with varied clonal types (monoclonal/polyoclonal), enhances accessibility for both basic and translational studies.

       
关键字: PRKD1抗体;PRKD1;PRKD1 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
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